摘要
目的 探讨奇曼丁 (曲马多缓释片 )对晚期癌症中度疼痛的疗效及其副作用。方法 总结分析 116例晚期癌症并中度疼痛患者使用奇曼丁治疗的效果 ,其中肺癌 5 5例 ,乳腺癌 2 0例 ,鼻咽癌 2 4例 ,消化道肿瘤 16例 ,多发性骨髓瘤 1例 ,并广泛骨转移 48例 ,内脏转移 32例 ,其它软组织转移 36例。结果 CR 5 0例 ,PR 30例 ,MR 2 2例 ,NR 14例 ,总有效率达 89.16 % ;副作用为眩晕 2 0例 ,恶心 15例 ,便秘 12例 ,嗜睡 2例。结论 奇曼丁能有效控制晚期癌症中度疼痛 ,但对于没有使用镇痛药史的病人宜从小剂量开始或先用普通片 3～ 5天后才改用缓释片至有效剂量 。
Objective To study the cruative effect and side effect of Tramcontin(release controlled Trammal tablet)on moderate pain of the advanced stage cancer patients.Methods Analysis on the treatment effect of Tramcontin on 116 cases of advanced stage cancer patients with moderate pain was made.This group included 55 cases of lung cancer,20 cases of breast cancer,24 cases of nasopharynx carcinoma, 16 cases of tumor of digestive tract, 1 case of multiple myeloma;48 cases with extensive bone metastasis,32 case with viscus metastasis,36 case with soft tissue metastasis.Results The total effective rate was 89.16%,including 50 cases of CR,30 cases of PR,22 cases of MR.The side effect included vertigo (20 cases),nausea (15 cases),constipation(12 cases);somnolence (2 cases).Conclusions Tramcontin is effective to control moderate pain of the advanced stage cancer patients.Patients free of analgesic drugs history should begin with low doses or begin with common tablet of Trammal for 3～5 days,then change to effective doses.If necessary,combination with nonsteroidal anti inflammatory drugs is a good choice.
出处
《中国肿瘤临床与康复》
2001年第2期108-109,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
奇曼丁
曲马多缓释片
晚期癌症
中度疼痛
治疗
Tramcontin
release controlled Trammal tablet
advanced stage cancer
moderate pain.
