摘要
目的:探讨广谱抗肿瘤新药榄香烯局部用药治疗颅内恶性肿瘤的效果;方法:局部用药治疗颅内恶性肿瘤19例(男11例、女8例,年龄11~61岁),共中恶性胶质瘤17例,脑转移瘤2例。采用经颅穿刺多点注药,有囊性变者先抽取囊液后,囊内注药。剂量:实质性肿瘤目的:探讨广谱抗肿瘤新药榄香烯局部用药治疗颅内恶性肿瘤的效果;方法:局部用药治疗颅内恶性肿瘤19例(男11例、女8例,年龄11~61岁),共中恶性胶质瘤17例,脑转移瘤2例。采用经颅穿刺多点注药,有囊性变者先抽取囊液后,囊内注药。剂量:实质性肿每次2~10mL,有囊液时注入量应少于抽出囊液量,1~2次/周,4次为一个疗程;结果:多数病人症状明显缓解。肿瘤消失(CR)者4例(21.05%)。肿瘤缩小50%者(PR)10例(52.63%),总缓解率(CR+PR)为73.68%,治疗前后肿瘤平均缩小54.04%(p<0.01);结论:榄香烯经肿瘤局部多点注射治疗颅内恶性肿瘤疗效显著,操作简单易行,副作用小,值得临床推广应用。
Objective: ST5,5BZToobservetheeffectofelemeneinthetreatmentofmalignantbraintumorswhenitwasadministratedbylocalinjection. Methods: 19casesenteredthestudy.AccordingtotheCTorMRItumorlocation,Wefirstaspirateinstracysticliquidandmixitwithelemene,theninjectthemintothecystandperiperaltumortissues.Thedosageislessthanthatofaspiration.Butthetotaldoseshouldnotbemorethan10mLatime.20%mannitolisneededwhenintracranialhypertensionispresent.CTorMRIexaminationshouldbeperformedafteronecouresoftreatment. Results:BZAmong19casesCR4cases;PR10casesSDlcases;PD4cases.Responesrate(CR+RP)isabout73.68%.Avreagevolumereductionis54.04%(P<0.01).Noobvioussideeffectoccured. Conclusion: Localinjectionofelemeneisaneffectivemethodforthetreatmentofmalignantbraintumors.
出处
《河北医学》
CAS
1999年第5期2-5,共4页
Hebei Medicine
关键词
榄香烯
局部化疗
颅内肿瘤
Elemene
Localchemotherapy
Malignantbraintumors