摘要
目的 :探讨术中输血对喉癌患者细胞免疫功能的影响。方法 :利用 EPICS- XL 型流式细胞仪对 36例喉癌手术患者于术前及术后 2周进行 T细胞亚群、NK细胞和 CD2 8测定 ,并与正常人及术中输异体血和非输血者进行比较。结果 :136例喉癌患者术前 CD3、CD4、NK细胞、CD2 8下降 ,与对照组比较 ,其差异均有显著性意义 (P<0 .0 1和 0 .0 5 )。 2输异体血组输血后 CD3、CD4、NK细胞、CD2 8下降 ,与治疗前喉癌组比较 ,其差异亦有显著性意义 (均 P <0 .0 5 )。 3非输血组术后 CD3、CD4、CD8、NK细胞、CD2 8与治疗前喉癌组比较 ,其差异均无显著性意义(均 P >0 .0 5 )。结论 :喉癌患者的细胞免疫功能普遍低下 ,术中输异体血会使患者的免疫功能进一步降低 ,使喉癌易于扩散与转移 ,应引起高度重视。
Objective:To explore the influence of blood transfusion on cellular immunofunction in patient with laryngeal carcinoma.Method:EPICS XL flow cytometry was used to measure T cell subgroup,NK cell and CD 28 in 36 patients with laryngeal carcinoma pre operation and 2 weeks post operation.Patients were divided into allotransfusion group and non transfusion group.Comparison was conducted between the 2 groups.Result:①Comparsion with normal population,decreasing of CD 3,CD 4,NK cell and CD 28 in the 36 patients pre operation was statistically significant (P< 0.01 ).②Decreasing of CD 3,CD 4,NK cell and CD 28 was statistically signficant post operation(P< 0.05 ).③In the non transfusion group change of CD 3,CD 4,CD 8,NK cell and CD 28 post operation was statistically insignificant (P> 0.05 ).Conclusion:While cellular immunofunction is generally low in patients with laryngeal carcinoma,allotransfusion will reduce further.It makes contribution to spreading and metastasis of carcinoma easier.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2001年第3期103-105,共3页
Journal of Clinical Otorhinolaryngology
关键词
喉肿瘤
T细胞亚群
输血
喉癌
细胞免疫功能
Laryngeal neoplasms
T Lymphocyte subsets
Blood transfusion
Natural killer cells
