摘要
上皮—间质转化(EMT)是指上皮细胞在特定的生理和病理情况下转化成有迁移能力的间质细胞的现象。近年来研究发现EMT与肿瘤的侵袭转移密切相关。生长因子、转录因子、microRNA等都可以参与各种信号通路来诱导或调控细胞发生EMT。本文就EMT现象及其与肿瘤侵袭转移的关系进行综述。
Epithelial-mesenchymal transition （EMT） is an important pathological and physiological transdifferentiation process by which a fully differentiated epithelial cell acquires mesenchy- mal traits. Recent years studies show that EMT plays a critical role in the process of metastasis, and the occurrence of EMT involves various of signaling pathways which related to growth factors ,transcription factors ,microRNA ,etc. In this review,we present the recent researches regarding the phenomenon of EMT and the correlation of EMT with tumor invasion and metastasis.
出处
《肿瘤学杂志》
CAS
2014年第6期508-511,共4页
Journal of Chinese Oncology
基金
广东省科技计划项目(2012B031800207)
关键词
上皮-间质转化
肿瘤侵袭转移
TGF-Β
epithelial-mesenchymal transition
tumor invasion and metastasis
TGF-β
