摘要
生长抑素及其类似物具有抑制肿瘤增殖或其异常分泌的作用。这些作用是通过肿瘤内高密度表达的生长抑素受体而介导的,并且具有受体亚型的选择性。人类消化系统肿瘤组织可表达多种SSTR,且大多数情况下同时表达两种以上的SSTR,其中以SSTR2和SSTR5最为常见,同一肿瘤不同分期状态下SSTR的表达状态也有所不同。明确肿瘤中生长抑素受体亚型的分布与表达,对选择特异性的生长抑素类似物,以及提高对肿瘤的诊治具有重要的意义。
Somatostafin and its analogues were powerful inhibitors of cell proliferation and hormone secretion. This action was mediated by high density expression of somatostatin receptor within the tumor,and was receptor subtype selectivity. Carcinomas of human digestive system can expressed a variety of SSTR, and at the same time, the majority of cases express more than two SSTRs. The SSTR2, and SSTR5 were the most common. The same tumor under different stages can express different SSTR. To make clear the expression and distribution of the SSTR of tumors were greatly significant to choose specific somatostatin analogues and to improve the diagnosis and treatment of tumor.
出处
《中华全科医学》
2011年第4期613-615,共3页
Chinese Journal of General Practice
基金
上海市嘉定区卫生局基金项目资助(2009-12-1)
