期刊文献+

大肠癌组织中Ezrin、HIF-1α的表达及意义 被引量:1

暂未订购
导出
摘要 用免疫组化SP法检测66例大肠癌组织(其中33例伴淋巴结转移)中Ezrin、HIF-1α蛋白的表达情况。结果在伴有淋巴结转移的癌组织中Ezrin、HIF-1α的阳性率分别为87.9%、94.0%,在无淋巴结转移的癌组织中的阳性率则为57.6%、66.7%(P均<0.01);二者与肿瘤分化程度、年龄、性别等无关(P均>0.05)。两种蛋白的表达存在正相关性(r=0.389,P<0.01)。认为伴淋巴结转移的大肠癌组织中Ezrin、HIF-1α蛋白的表达上调;Ezrin、HIF-1α的表达可能与肿瘤的侵袭转移相关。
出处 《山东医药》 CAS 北大核心 2007年第36期81-82,共2页 Shandong Medical Journal
  • 相关文献

参考文献5

  • 1Wiesener MS,Munchenhagen PM,Berger I,et al.Constitutiveactivation of hypoxia-inducibl-e genes related to overexpression of hypoxiainducible factor-1 alpha in clear cell renalcarcinomas[J].Cancer Res,2001,61 (13):5215 -5222.
  • 2朱明华.组织微阵列及其在肿瘤病理研究中的应用[J].中华病理学杂志,2002,31(1):72-74. 被引量:26
  • 3Mathew J,Hines JE,Obafunwa JO,et al.CD44 is expressed in hepatocellular carcinomas sho-wing vascular invasion[J].J Pathol,1996,179(1):74 -79.
  • 4Mc Clatchey AI.Merlin and ERM proteins:un-appreciated roles in cancer development[J].Nat Rev Cancer,2003,3 (11):877-883.
  • 5Semenzz GL.HIF-1 and tumor progression:pa-thophysiology and therapeutics[J].Trends MolMed,2002,8 (4):62-67.

二级参考文献16

  • 1Venter JC, Adams MD,Myers EW, et al. The sequence of the human genome. Science,2001,291:1304-1351.
  • 2Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med,1998,4:844-847.
  • 3Comp RL, Charette LA, Rimm DL. Validation of tissue microarray technology in breast carcinoma. Lab Invest,2000,80:1943-1949.
  • 4Perrone EE,Theoharis C,Mucci NR, et al. Tissue microarray assessment of prostate cancer tumor proliferation in African-American and white men. J Natl Cancer Inst, 2000,92:937-939.
  • 5Bubendorf L,Kolmer M,Kononen J,et al. Hormone therapy failure in human prostate cancer:analysis by complementary DNA and tissue microarrays. J Natl Cancer Inst,1999,91:1758-1764.
  • 6Moch H, Schraml P, Bubendorf L, et al. High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray secreening in renal cell carcinoma. Am J Pathol, 1999,154:981-986.
  • 7Richter J, Wagner U, Kononen J, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol, 2000, 157:787-794.
  • 8Welsh JB, Zarrinkar PP,Sapinoso LM, et al. Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci U S A, 2001,98:1176-1181.
  • 9Sallinen SL,Sallinen PK,Haapasalo HK, et al. Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res,2000,60:6617-6622.
  • 10Schraml P,Kononen J,Bubendorf L, et al. Tissue microarrays for gene amplification surveys in many different tumor types. Clin Cancer Res,1999,5:1966-1975.

共引文献25

同被引文献15

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部