摘要
目的观察双水平无创正压通气(BiPAP)在急性左心衰竭中的应用效果。方法将60例急性左心衰竭患者分为观察组(n=35)和对照组(n=25)。对照组患者给予常规处理,观察组患者在常规处理基础上同时接受无创BiPAP辅助呼吸,观察治疗前、治疗后1 h 2组的临床症状、动脉血气分析参数、呼吸频率(RR)、心率(HR)、平均动脉压(MAP)、氨基末端B型利钠肽前体(NT-proBNP),并进行比较。结果 2组患者治疗后1 h氧分压、二氧化碳分压、RR、HR、MAP、NT-proBNP均较治疗前明显改善,差异有统计学意义(P<0.05);与对照组患者比较,观察组患者在包括pH在内的各项指标均有明显改善,差异有统计学意义(P<0.05)。观察组35例患者中31例治疗有效,有效率达88.57%;对照组25例患者中18例治疗有效,有效率为72.00%;2组患者治疗有效率比较差异有统计学意义(P<0.05)。结论急性左心衰竭患者早期使用BiPAP可快速减轻临床症状,是一种有效的辅助治疗方法。
Objective To investigate the therapeutic efficacy of bilevel positive airway pressure（ BiPAP） non-invasive ventilation in acute left heart failure. Methods Sixty patients with acute left heart failure were divided into observation group（ n =35） and control group（ n =25）. The patients in control group were given conventional therapy; based on this,the observation group was given BiPAP non-invasive ventilation. The clinical symptoms,arterial blood gas analysis parameters,respiratory rate（ RR）,heart rate（ HR）,mean arterial pressure（ MAP）,N-terminal pro-brain natriuretic peptide（ NT-proBNP） were observed and analyzed before treatment and 1 hour after treatment in the two groups. Results Compared with before treatment, the oxygen partial pressure（ PaO2）,carbon dioxide partial pressure（ PaCO2）,RR,HR,MAP and NT-proBNP were improved significantly 1 hour after treatment of the two groups（ P 0. 05）. Compared with the control group,all indicators of the observation group were improved significantly（ P 0. 05）. The effective rate of observation group and control group was 88. 57%（ 31 / 35） and 72. 00% respectively; there were statistic difference of the effective rates between the two groups（ P 0. 05）. Conclusion Early use of BiPAP in patients with acute left heart failure can quickly relieve clinical symptoms,and is an effective auxiliary treatment.
出处
《新乡医学院学报》
CAS
2014年第6期461-463,共3页
Journal of Xinxiang Medical University
关键词
急性左心衰竭
双水平无创正压通气
氨基末端B型利钠肽前体
acute left heart failure bilevel positive airway pressure non-invasive ventilation N-terminal pro-brain natriuretic peptide
