摘要
目的分析奥美沙坦对慢性心力衰竭患者血浆脑钠肽、IL-23含量及左室舒张功能的影响。方法选取2010年6月～2012年6月我院收治的慢性心力衰竭患者78例作为研究对象，随机分为观察组和对照组。对照组予普通的对抗慢性心衰药物；观察组在对照组的基础上予奥美沙坦治疗，治疗8周后比较患者的血浆脑钠肽、IL-23的水平及左室舒张功能的变化。结果两组患者治疗8周后脑钠肽水平均明显降低，且观察组较对照组降低更明显，观察组的IL-23水平较对照组明显增高，差异有统计学意义（P〈0．05）。两组患者治疗前后的超声心动图比较，对照组患者的LAD明显减小，差异有统计学意义（P〈0．05），余无明显变化。观察组患者的LAD、LVPWD、LVEDD均明显减小，差异有统计学意义（P〈0．05）。观察组E／A明显增大。结论奥美沙坦治疗慢性心力衰竭有显著的疗效，且能有效的降低其血浆脑钠肽、IL-23水平，并调节其舒张功能，值得临床应用与推广。
Objective To test and analyze the effects of olmesartan on the plasma brain natriureticpeptide, IL-23 and left ventricular diastolic functions of the patients with chronic heart failure. Methods From July 2010 to June 2012, 78 patients with chronic heart failure in our hospital were chosen as study objects.They were randomly divided into the ob- servation group and the control group. The control group was given ordinary drugs for chronic heart failure, the observa- tion group was treated with olmesartan on the basis of the control group.And the changes of olmesartan on the plasma brain natriureticpeptide, IL-23 and left ventricular diastolic functions of the patients were compared after 8 weeks treatment. Results After treatment 8 weeks, the plasma brain natriuretiepeptide was decreased whether in observation group or in control group, and the dose of observation group was obviously reduced compared with the control group, the difference was significant （P〈0.05）. While comparing all datas of ultrasonic heartbeat graph before and after treat- ment,the LAD of control group patients was obviously decreased, the difference was significant（P〈0.05）, and there were no changes in other aspects.The LAD, LVPWD, LVEDD of control group decreased significantly, the difference was significant （P〈0.05）. The E / A of observation group increased significantly. Conclusion Olmesartan has significant effects in the treatment of chronic heart failure, which can decrease the plasma brain natriureticpeptide and IL-23 level of the patients effectively, it is worthy of further studies and wide popularizations in clinic.
出处
《中国现代医生》
2014年第13期59-61,64,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划(2011RCA005)
