摘要
Angiotensin converting enzyme 2 （ACE2） is a new member of renin-angiotensin system found recently. It counterbalances the effects of angiotensin converting enzyme （ACE）, hydrolyzes angiotensin Ⅱ to generate angiotensin-（1-7） and hydrolyzes angiotensin Ⅰ to produce angiotensin-（1-9）. Angiotensin-（1-9） can be hydrolyzed by ACE to form angiotensin-（1-7）, and angiotensin-（1-7） counteracts the effects of angiotensin Ⅱ in many aspects. Bradykinin or atrial natriuretic factor or substance P are not the substrates of ACE2, and ACE2 hydrolyzes the metabolites of bradykinin such as des-Arg9-BK and des-Arg10-kallidin, and also the dynorphin A, one of the opium peptides. ACE2 is not inhibited by angiotensin-converting enzyme inhibitor （ACEI）. Recent studies demonstrate that ACE2 is a functional receptor of SARS coronavirus. To elucidate the mechanisms of cardiovascular diseases and other disease such as SARS, further investigations in ACE2 are needed.
Angiotensin convening enzyme 2 （ACE2） is a new member of renin - angiotensin system found recently. It counterbalances the effects of angiotensin convening enzyme （ACE）, hydrolyzes angiotensin Ⅱ to generate angiotensin- （1 -7） and hydrolyzes angiotensin Ⅰ to produce angiotensin - （ 1 - 9）. Angiotensin - （ 1 - 9） can be hydrolyzed by ACE to form angiotensin - （ 1 - 7）, and angiotensin - （ 1 - 7） counteracts the effects of angiotensin Ⅱin many aspects. Bradykinin or atrial na- triuretic factor or substance P are not the substrates of ACE2, and ACE2 hydrolyzes the metabolites of bradykinin such as des - Arg^9 - BK and des - Arg^10- kallidin, and also the dynorphin A, one of the opium peptides. ACE2 is not inhibited by angiotensin - convening enzyme inhibitor （ ACEI）. Recent studies demonstrate that ACE2 is a functional receptor of SARS coronavirus. To elucidate the mechanisms of canfiovascular diseases and other disease such as SARS, further investigations in ACE2 are needed.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第9期1858-1863,共6页
Chinese Journal of Pathophysiology
基金
国家教育部博士基金资助项目(No.20020558064)
