摘要
粉防己碱可显著降低ＤＯＣＡ盐性高血压心肌肥厚大鼠的血压，左室湿重；在工作心脏研究中发现其改善肥厚心室的收缩（ＡＰ，ＬＶＳＰ，＋ｄｐ／ｄｔｍａｘ）舒张（一ｄｐ／ｄｔａｍｘ，ＬＶＥＤＰ，Ｔ值）性能，尤以舒张性能改善明显，并恢复泵功能（ＣＯ）和冠脉流量（ＣＦ）；在左室压力容积关系法研究显示有改善肥厚心室左室顺应性和左室僵硬度的作用。提示：Ｔｅｔ有逆转心肌肥厚和改善肥厚心肌舒张收缩功能，左室顺应性和心肌劲度的作用。
Effects of tetrandrine(Tet)on
cardiac mass and hemodynamic parameters were studied in
deoxycorticosterone-salt(DOCA-salt )hypertensive rats. Treatment with
Tet(50mg·kg-1,qd X 9 wk)markedly lowered systolic blood pressure and
left ventricular(LV) weight,Study on isolated working heart
demonstrated that the Tet group compared with the LVH group, AP,LVSP,
±dp/dtmax, LVDP,coronary blood flow and cardiac output were
increased while LVEDP andT were decreased. Studies on LV
pressure-volume relation showed that Tet can markedly improve theLV
compliance and the LV stiffness constant of LVH ra. These findings
suggest that the regression ofLVH in DOCA-salt hypertensive rats with
Tet is associated with improvement of the contraction,relaxation and
pump function , especially relaxation function and hemodynamics.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第2期86-92,共7页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
粉防己碱
左心室顺应性
左室肥厚
血液动力学
Left ventricular hypertrophy
Hemodynamics
Tetrandrine :
Deoxycorticosterone
Left ventricular compliance
