摘要
目的 探讨TNF α在原发性肾病综合征 (PNS)发病中所起的作用。方法 检测 40例PNS患者和 10名正常人血、尿、肾组织TNF α含量。 40例PNS患者接受糖皮质激素常规治疗。分别于治疗后 1、2、4、8周复查血、尿TNF α水平 ,并与正常人血、尿TNF α水平进行比较。结果 40例PNS患者肾组织局部、血、尿TNF α均较正常对照组明显增高 (P <0 .0 1)。激素治疗后显效31例 ,无效 9例 ,显效率为 77.5 %。显效者血、尿TNF α早期即开始下降 ,而激素治疗无效者血、尿TNF α无明显变化。血、尿TNF α与血尿素氮 (BUN)、血肌酐 (Scr)、2 4h尿蛋白定量 (Pro)明显正相关 ;与内生肌酐清除率 (Ccr)明显负相关。结论 TNF α参与PNS发病及疾病进展 ;激素治疗PNS有效 ,其作用机制可能与其抑制TNF α产生有关 ;血、尿TNF α可作为评价PNS发病及疾病活动性的一个临床指标。
Objective To investigate the role of TNF α in occurrence of primary nephrotic syndrome(PNS).Methods The plasma, uria and renal tissue levels of TNF α were tested in 40 PNS patients and 10 health doners. After treatment with corticosteroids, the plasma and uria levels of TNF α were checked again and compared with normal control group.Results The renal tissue, plasma and uria levels of TNF α in 40 patients elevated obviously as compared the normal controls(P<0.01). After treatment with corticosteroids, 31 cases were treat effectively and their plasma and uria levels of TNF α decreased rapidly while 9 cases were ineffectivelly and their plasma and uria levels of TNF α were unchanged (P>0.05). The plasma and urine TNF α had positive correlation with BUN, Scr, Pro(24 hour's urinary protein volume) and negative correlation with Ccr.Conclusion TNF α participates in with occurrence and development of primary nephrotic syndrome. The effect mechanisms of corticosteroids can treat PNS, being related to inhibition in production of TNF α. Plasma and uria levels of TNF α can be served as an clinical index of estimating occurrence and activity of PNS.
出处
《临床内科杂志》
CAS
北大核心
2001年第1期50-52,共3页
Journal of Clinical Internal Medicine
