摘要
目的 探讨肿瘤坏死因子 (TNF α)在人系膜增生性肾小球肾炎中的表达及其在发病中的作用。方法 采用HE ,PAS ,PASM及免疫组织化学方法对 13例系膜增生性肾小球肾炎进行染色观察。结果 TNF α阳性反应见于肾近曲小管上皮细胞和肾小球内 ,且阳性反应强度与HE ,PAS等显示的病变程度一致。结论 TNF
Objective To study the role of tumor necrosis factor (TNF α) in the development of human mesangial proliferative glomerulonephritis.Method Histotopathological (HE,PAS,PASM) analysis and immuno histochemistry were used to evaluate the change and the expression of TNF α in the tissues of kidney.Result The results showed that TNF α positive reaction were found in glumeruli and renal tubles and also reveal a relationship between the increased expression and severity of the lesions.Conclusion Increased expression of TNF α may play a important role in the pathological accumulation of extracellular matrix and renal interstitial fivrosis in mesangial proliferative glomeralonephritis.
出处
《潍坊医学院学报》
2001年第4期308-309,W006,共3页
Acta Academiae Medicinae Weifang
基金
山东省卫生厅资助课题 (课题号 :1 997 0 1 2号 )
关键词
系膜增生性肾小球炎
肿瘤坏死因子
免疫组织化学
Mesangial proliferative glomerulonephritis
Tumor necrosis factor (TNF-α)
Immunohistochemistry
