摘要
目的 观察原发性肾病综合征 (PNS)患者应用糖皮质激素 (以下简称激素 )前后血、尿ET 1变化。方法 检测 40例PNS患者激素治疗前及用激素后 1、2、4、8周血、尿ET 1变化 ,并与 2 0例正常人血、尿ET 1进行比较。结果 40例PNS患者治疗前血、尿ET 1明显增高 (P <0 .0 1)。激素治疗后 31例患者显效 ,9例无效 ,显效率 77.5 % ;显效者血、尿ET 1早期即开始下降 ,而激素治疗无效者血、尿ET 1无明显变化。结论 激素治疗PNS的作用机制可能与其间接抑制ET 1产生有关 ;血、尿ET 1可作为判断激素疗效与预后的参考指标。
Objective To investigate the effect of corticosteroids on the plasma and urinary level of endothelin 1(ET 1) in patients with primary nephrotic syndrome(PNS).Methods Plasma and urinary ET 1 level was determined by RIA in 20 healthy control and 40 PNS patients before and after the corticosteroids therapy.Result Before treating with corticosteroids, the plasma and urinary level of ET 1 in 40 patients were significantly higher than in healthy donors ( P <0.01).After treating with corticosteroids, 31 cases were effectually and their plasma and urinary level of ET 1 decreased rapidly while 9 cases were ineffectually and their plasma and urinary level of ET 1 were unchanged( P >0.05).Conclusion The effect mechanisms of corticosteroids can correlate with inhibition in production of ET 1.Plasma and urinary level of ET 1 can serve as an index of the effect of corticosteroids on the PNS patients.
出处
《铁道医学》
2000年第5期297-299,共3页
Railway Medical Journal
