摘要
目的：探讨子宫内膜异位症（EMs）患者血清和腹腔液中CA125、TNF-α水平的变化及其与子宫内膜异位症的相关性。方法：把52例内异症患者按r-AFS分期法分为I-N期，其中I- II期为I组共21 例，ill-N期为H组共31例。采用ELISA法检测血清及腹腔液中TNF-α含量，并采用基因芯片法检测血清及腹腔液中CA125的含量。结果，II纽血清中CA125、 TNF-α的浓度与I组血清中CA125、TNF-α的浓度比较均无统计学差异（ P 〉 O. 05）; II组腹腔液中CA125、TNF-α的浓度与I组腹腔液中CA125、TNF-α的浓度比较有统计学差异（P〈0. 05） ;两组患者腹腔液中CAl25、TNF-α的浓度分别高于同组血清中CAl25、TNF-α的浓度（P〈0. 05）。结论：子宫内膜异位症患者血清及腹腔液中CA125、TNF-α与疾病的发病机制密切相关， 腹腔液在监测子宫内膜异位症发生发展中可能较血清有更灵敏、更可靠的诊断价值。
Objective： To investigate the levels of carbohydrate antigen 12S and tumor necrosis factor - alpha （ TNF - a） in serum and peritoneal fluid of patients with endometriosis, and to analyze the correlation between endometriosis and them. Methods： 52 patients with endometriosis were divided into two groups ： the I - II stage patient （21 cases） were the first group, the ill - N stage patients （ 31 cases） were the second group. Enzyme - linked immuno sorbent assay （ELISA） was used to determine the level of TNF - aand gene chips was used to determine the level of CAl25. Results： The levels of CAl25 and TNF - Ci in the serum and peritoneal fluid had no differences between the first group and the second group （P 〉 O. OS）; the levels of CAl25 and TNF - Ci in the peritoneal fluid showed a marked difference between the first group and the second group （P 〈 0. 05） ; there were significantly higher levels of CAl25 and TNF - Ci in the peritoneal fluid than in the serum （P 〈 0. 05） . Conclusion： The levels of CAl25 and TNF - a in the serum and peritoneal fluid are closely related to endometriosis. The peritoneal fluid in monitoring of endometriosis may be more sensitive and reliable than the serum.
出处
《中国妇幼保健》
CAS
北大核心
2014年第8期1196-1198,共3页
Maternal and Child Health Care of China
