摘要
目的 通过检测子宫内膜异位症（EMS）患者腹腔液和血清白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）水平,探讨其在EMS发病机制中的作用. 方法 采用酶联免疫吸附双抗体夹心法（ELISA）检测60例EMS患者（Ⅰ、Ⅱ期34例,Ⅲ、Ⅳ期26例）及30例对照组（同期非EMS患者）腹腔液和血清IL-6、TNF-α水平. 结果 EMS患者腹腔液和血清IL-6、TNF-α水平明显高于对照组（P＜0.01）,且Ⅲ、Ⅳ期EMS患者腹腔液及血清IL-6、TNF-α水平明显高于Ⅰ、Ⅱ期（P＜0.01）. 结论 EMS患者腹腔液和血清IL-6、TNF-α在EMS的发生、发展中均起着重要的作用.
Objective To study the levels of interleukin-6（IL-6）and tumor necrosis factor-alfa（TNF- α）in serum and peritoneal fluid of women with endometriosis,to explore their roles in pathogenesis of endometriosis. Methods IL-6 and TNF-α levels in peritoneal fluid and serum of 60 patients with endometriosis（34 cases in Ⅰ ～ Ⅱ stage,26 cases in Ⅲ ～ Ⅳ stage）and 30 control cases（not EMS patients）were detected by enzyme linked immunosorbent assay（ELISA）. Results Peritoneal fluid and serum levels of IL-6 and TNF-α in EMS group were significantly higher than that in control group（P〈0.01）,and peritoneal fluid and serum levels of IL-6 and TNF-α in Ⅲ ～Ⅳ stage was siguificantly higher than that in Ⅰ ～ Ⅱ stage（P〈0.01）. Conclusion IL-6 and TNF-α in peritoneal fluid and serum played an important role in pathogenesis of endometriosis.
出处
《中国基层医药》
CAS
2010年第16期2179-2180,共2页
Chinese Journal of Primary Medicine and Pharmacy
