摘要
目的 :评价樟脑油精喷剂的药效及其在使用中的安全性。方法 :将樟脑油精涂于裸露皮肤上 ,进行驱蚊试验 ;取白色念球菌 (ATCC10 2 31)悬液加入樟脑油精 ,观察对真菌的抑制作用 ;急性经口毒性试验采用一次性灌胃给药 ;急性皮肤刺激和眼刺激试验直接涂药于家兔皮肤和滴药于眼结膜囊内。结果 :驱蚊保护时间达 6h以上 ;抑菌率达 99.99% ;小鼠急性经口LD50 为 130 2 .2 5mg/kg ;对家兔皮肤刺激积分值为 0 ,48h后对眼刺激平均指数为 0 .5。结论 :本品对蚊虫有一定驱避保护作用 ,对霉菌生长有较强的抑制作用 ,而且毒性低 。
Objective:To evaluate repellent efficacy,fungistatic efficacy and safety of the camphor oil spray.Method:Place the human volunteer's hand treated with the camphor oil inside a cage containing 300 Aedes albopictus ,for 2 min, and observe the treated skin surface for mosquitoes which landed and attempted to feed. Mingle the camphor oil and the fungous suspension, Candida albicans ,culture and count the number of mold.Infuse the mice with the spray by single oral injection,and treat directly the rabbits' exposed skin and the conjunctiva crypt with the spray.Result:The repellent protection time against Aedes albopictus was over 6h. Mean fungistatic rate to mold was 99.99 %. The acute oral LD 50 was 1 302.5 mg/kg in mice. This product was non-irritant to skin,but slightly irritant to eye. Conclusion:The camphor oil spray is a better repellency against mosquito,inhibitor against mold,and low acute toxicity substance.
出处
《中国媒介生物学及控制杂志》
CAS
CSCD
2001年第1期58-60,共3页
Chinese Journal of Vector Biology and Control
