摘要
目的 :探讨中药针剂葛根素加脉安定早期静滴防治急性心肌梗死 (AMI)再灌注损伤的效果。方法 :对 10 2例AMI患者随机分为试验组和对照组 ,每组 51例 ;试验组采用葛根素加脉安定 ,对照组用极化液 ;溶栓和其他治疗两组均常规进行。结果 :两组HR、mBP无明显差异 ,试验组O2 max、RA显著减少 (P <0 .0 5和P <0 .0 1) ;CK、CK MB和HBD峰值显著低于对照组 ,且降至正常值的时间明显缩短 (P <0 .0 1) ;WBC平均总数和中性平均百分比在 4 8h～ 5d试验组显著降低 (P <0 .0 5) ;BUN、Cr治疗前后试验组差异有显著性 (P <0 .0 5) ,对照组差异无显著性 ;MIER为 7.8% ,其中试验组为 5.9% ,对照组 9.8%。综合疗效评价试验组达 96.1% ,对照组为 82 .4 % (P <0 .0 1)。结论 :葛根素加脉安定对急性心梗再灌注损伤有明显的防治效果。
Objective:To evaluate the therapeutic effect of Puerarin and Panangin on reperfusion injury(RI) in the early period of acute mycardial infarction (AMI). Methods:102 cases were randomly divided into two groups.Puerarin and Panangin were used in test group,and GIK in control group.Results:HR and mBP in both groups had no significant difference,but the O 2max and RA notably decreased in test group (P< 0.05 ,P<0.01).The peak value of CK, CK MB and HBD in test group was lower than that in control group,and the time of reaching normal value of the 3 indices was markedly shortened in test group(P<0.01).The average value of total WBC and neutral percent were obviously decreased in test group (P<0.05)during 48h～5d.Both BUN and Cr before and after treatment showed significant difference in test group(P<0.05) and nonsignificant difference in control group.Average MIER was 7.8%(8/102),and 5.9%(3/51)in test group,9.8%(5/51)in control group.General curative rate reached 96.1% in test group and 82.4% in control group(P<0.01).Conclusion:Puerarin and Panangin has obvious preventive and therapeutic efficacy on reperfusion injury of acute myocardial infarction.
出处
《山东医科大学学报》
2000年第4期360-363,共4页
Acta Academiae Medicinae Shandong
基金
山东省中医药管理局科研基金资助课题
关键词
葛根素
脉安定
心肌梗死
再灌注损伤
Puerarin
Panangin
Myocardial infarction
Reperfusion injury
