摘要
为探讨葛根素加脉安定早期静滴防治糖尿病并发急性心肌梗死 (AMI)时再灌注损伤的疗效 ,将 5 8例糖尿病并发 AMI患者随机分为两组 ,治疗组采用葛根素加脉安定治疗 ,对照组用极化液 ,两组均常规用溶栓和其他治疗。结果显示 ,两组心率 (HR)、平均动脉压 (m BP)无明显差异 ;治疗组最大耗氧指数 (O2 m ax)、再灌注心律失常 (RA )显著减少 (P<0 .0 5、<0 .0 1) ;肌酸激酶 (CK)、肌酸激酶同功酶 (CK- MB)和羟丁酸脱氢酶 (HBD)峰值显著低于对照组 ,且降至正常值的时间明显缩短 (P<0 .0 5 ) ;心脏功能较对照组显著改善 (P<0 .0 5 ) ,C反应蛋白(CRP)、血 WBC和中性分类均明显低于对照组 (P<0 .0 5 )。综合疗效评价治疗组达 93.7 ,对照组为 76 .9 (P<0 .0 1)。认为葛根素加脉安定早期静滴防治糖尿病并发 AMI时再灌注损伤疗效显著。
To evaluate the therapeutic effect of Puerarin and Panangin on reperfusion injury(RI) by dripping at the thromboclasis period of acute mycardial infarction (AMI) with diabetic. 58 cases were randomly divided into two groups, the test group(32) and control group(26). Puerarin and Panangin were used in the test group , and GIK was used in the control group.The results showed that the HR and mBP in 2 groups had no obvious discrepancy, but the O_2max and reperfusion arrhythmia(RA) notably decreased in test group (P<0.05? <0.01). The peak value of CK,CK-MB and HBD in test group were lower than that in control group, and the time of reaching normal value of the 3 indices was markedly shortened in test group (P<0.01).The heart function was markedly improved, and the CRP average value,of total WBC and neutral percent were obviously decreased in test group and control group (P<0.05 ).General appraise of curative effect reached 93.7% in test group and 76.9% in control group (P<0.01).This suggest that Puerarin and Panangin has obviously preventive and therapeutic efficacy on reperfusion injury at the thromboclasis period of acute mycardial infarction with diabetic.
出处
《山东医药》
CAS
北大核心
2002年第1期13-15,共3页
Shandong Medical Journal
基金
山东省中医管理局科研基金资助课题 ( NO:1999第 2 8号 )
