摘要
目的:探讨络脉舒通冲剂对急性心肌梗死急诊经皮冠状动脉介入治疗(PCI)病人心肌的保护作用及可能机制。方法:选ST段抬高急性心肌梗死(AMI)病人,分络脉疏通组(30例)和对照组(31例),络脉疏通组给予PCI+常规药物+络脉舒通治疗,对照组给予PCI+常规药物治疗,疗程2 wk。入院后即刻,PCI术后24h、7d抽取静脉血,测定白细胞介素-6mRNA(IL-6mRNA)及高敏C反应蛋白(hs- CRP)。同时,观察PCI术后心律失常、心电图ST段回落?结果:PCI术后24h,2组病人IL-6 mRNA及hs-CRP含量均升高,但络脉疏通组显著低于对照组(P＜0．05)。且PCI术后2h、24h、7d,络脉疏通组心律失常发生率均明显低于对照组(P＜0．05),心电图ST段回落率均显著高于对照组(P＜0．05)。术后7d,IL-6 mRNA及hs-CRP含量均较前进一步明显降低(P＜0．01),络脉疏通组较对照组降低更显著(P＜0．01)。结论:络脉舒通具有抑制PCI术后炎症反应,抗心肌缺血-再灌注损伤,改善心肌组织再灌注的作用。
AIM： To investigate the protective effects and mechanism of Luomaishutong powder on myocardium after percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI） . METHODS： AMI patients with ST segment elevation after PCI were divided into two groups. Thirty patients in the treatment group were given Luomaishutong and routine treatment, and 31 patients in the control group were given routine treatment for 2 wk. Serum IL-6 mRNA and hs-CRP levels were tested before PCI and d 1, d 7 after PCI. Incidences of arrhythmogenesis and the rate of ST segment resolution after PCI were also observed. RESULTS： The 24 h after PCI, IL-6 mRNA and hs-CRP levels in two groups increased, while IL-6 mRNA and hs-CRP in the treatment group were obviously lower than those in the control group （P 〈 0.05）. The incidence of arrhythmogenesis, 2 h, 24 h and 7 d after PCI in the treatment group, was apparently lower than that in the control group （P 〈 0.05）, and the rate of ST segment resolution in the treatment group were more than that in the control group （P 〈 0.05）. Seven days after operation, IL-6 mRNA and hs-CRP in both groups decreased significantly （P 〈 0.01 ）. Compared with the control group, IL-6 mRNA and hs-CRP in the treatment group were apparently lower （P 〈 0.01 ）. CONCLUSION： Luomaishutong powder could inhibit inflammation after PCI, reduce myocardial ischemia-reperfusion injury, and improve myocardial reperfusion.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2007年第4期272-275,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
山东省中医管理局基金(2006046)
关键词
心肌梗死
血管成形术
经腔
经皮冠状动脉
支架
心肌再灌注损伤
络脉舒通
myocardial infarction
angioplasty, transluminal, percutaneous coronary
stents
myocardial reperfusion injury
Luomaishutong
