摘要
分别观察黄芩甙和维拉帕米对大鼠离体主动脉条收缩张力的影响。发现：黄芩甙和维拉帕米均可使ＮＥ、ＫＣｌ及ＣａＣｌ２所致的大鼠离体主动脉条收缩张力下降，量效反应曲线右移，最大效应降低。黄芩甙的抑制作用弱于维拉帕米。２药均显著抑制ＮＥ依赖内Ｃａ２＋性收缩与外Ｃａ２＋性收缩。提示黄芩甙具有类似维拉帕米的阻滞钙离子通道的作用。
Baicalin(Bai) and verapamil(Ver) inhibited the contractions of isolated rat aortic strips evoked by norepinephrine(NE),KCl and CaCl 2. They also caused the dose response curves to shift rightward and depressed the maximal response,but Bai was less potent than Ver. Both Bai and Ver inhibited the fast contraction responses evoked by NE in Ca 2+ free medium and slow Ca 2+ dependent component on contraction. The results indicated that Bai like Ver, may be a calcium antagonist.
出处
《首都医科大学学报》
CAS
1997年第2期114-117,共4页
Journal of Capital Medical University
关键词
黄芩甙
主动脉条收缩
baicalin
verapamil
norepinephrine
KCl
CaCl 2
aorta
