摘要
目的 探讨 CA2 42 ,CA5 0和层粘连蛋白 (L N )水平与大肠癌转移及病理分期的关系 .方法 采用放射免疫分析法 .结果 38例大肠癌患者术前 CA2 42 ,CA5 0和 L N血清含量明显高于术后 (P<0 .0 1,P<0 .0 5和 P<0 .0 5 ) ;2 7例有淋巴结转移者 CA2 42 ,CA5 0及 L N血清含量明显高于 11例无淋巴结转移者 (P<0 .0 1,P<0 .0 5和 P<0 .0 5 ) ;Dukes病理分期中 ,CA2 42血清含量 期组 (16例 )高于 期组 (11例 ) , 期组高于 + 期组 (11例 ) ,差异均非常显著 (P<0 .0 1) ;CA5 0血清含量 , 期组和 期组均明显高于 + 期组 (P<0 .0 1) ;L N血清含量 , 期组高于 + 期组 (P<0 .0 5 ) .结论 CA2 42 ,CA5 0含量与大肠癌的病理分期和转移密切相关 。
AIM To investigate the relation of serum of levels CA242,CA50 and laminin (LN) with metastases and pathologic stages of large intestine cancer. METHODS Three tumor markers were detected by radioimmunoassay. RESULTS Serum levels of CA242,CA50 and LN of 38 patients with large intestine cancer before operations were apparently higher than those after operations ( P <0.01, P <0 05 and P <0.05 respectively); the contents of CA242, CA50 and LN in sera of 27 patients with lymphold node metastases were apparently higher than those of 11 cases without the metastases ( P <0.01, P <0.05 and P <0.05 respectively). The 38 patients were divided into three groups by Dukes pathologic stage. The contents of CA242 in sera of patients at stage Ⅳ(16 cases) were higher than those of patients at stage Ⅲ(11 cases), and the latter was higher than those of patients at Ⅰ+Ⅱ(11 cases). The differences among the three groups were all very significant( P <0.01). The contents of CA50 in sera of stage Ⅲ and Ⅳ groups were apparently higher than those of stage Ⅰ+Ⅱ group( P <0.01). The content of LN in sera of patients at stage Ⅲ group was higher than that of stage Ⅰ+Ⅱ group( P <0.05) CONCLUSION There was close correlation between contents of CA242, CA50 and LN in sera and pathological stages and metastases of large intestine cancer. These results may be of clinical benifit to the monitoring of patients' conditions.
出处
《第四军医大学学报》
2000年第10期1238-1240,共3页
Journal of the Fourth Military Medical University
