摘要
特应性皮炎是一种慢性、复发性和炎症性皮肤病,以皮肤干燥、瘙痒和湿疹样外观为主要临床表现。其发病机制复杂,皮肤屏障功能障碍可能是其发生的源头。保湿润肤剂可以补充皮肤水分和脂质,增加水合作用,减少经皮失水率,阻止外界有害物质入侵。润肤剂联合糖皮质激素治疗还可以减少激素用量,减轻其不良反应。传统的润肤剂含有非生理性脂质和表面活化剂,长期应用会破坏皮肤屏障含有神经酰胺的润肤剂作为本病的基础治疗方案,已被应用于各种年龄段的患者中,且耐受性好,也无严重的不良反应,故具有较高的安全性和有效性。
Atopic dermatitis（AD） is a chronic, recurrent inflammatory disease, with xerosis curls, pruritus and eczema appearance as the main clinical manitestations. Its pathogenesis was complicated. Dysfunction of skin barrier may be the cause of the disease. Emollient could replenish skin moisture and lipid, increase the hydration, reduce the trans-epidermal water loss and block the invasion of harmful substances. A combination treatment of emollient and glucocorticoid could reduce the dosage of glucocortieoids and reduce its side effects. The tra- ditional emollient contains non-physiologic lipids and surfactants, and long-term use can damage the skin barrier. Ceramide-containing emollient, a basic treatment for AD, has been used in various age groups of pa- tients with good tolerability and without serious untoward reactions, so it has higher safety and effectiveness.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第1期81-83,共3页
The Chinese Journal of Dermatovenereology
关键词
特应性皮炎
保湿
润肤剂
皮肤屏障
Atopic Dermatitis
Moisturize
Emollient
Skin barrier
