摘要
目的:评价Artemin蛋白在胃癌组织中的表达情况及其与胃癌临床病理特征的关系。方法:应用免疫组化的方法检测122例胃癌组织和98例癌旁正常胃组织中Artemin蛋白的表达情况,分析其与胃癌临床病理特征之间的关系。结果:胃癌组织中Artemin蛋白阳性表达率(77.1%,94/122)高于癌旁正常胃组织(16.3%,16/98;χ2=80.154,P<0.001)。Artemin蛋白阳性表达率随着胃癌浸润程度的加深和TNM分期的增加而逐渐升高(P均<0.05);Artemin蛋白的表达与淋巴结转移有关(χ2=17.835,P<0.001),与胃癌的分化程度、患者的性别、年龄无关(P均>0.05)。结论:Artemin可能参与了胃癌的发生发展,且与侵袭转移密切相关。
Aim：To investigate the expression of Artemin protein in gastric carcinoma tissue and its relationship with clinicopathologic features of gastric carcinoma. Methods：Immunohistochemistry was used to detect the expression of Artemin protein in 122 cases of gastric cancer tissue and 98 cases of normal gastric mucosa. The relationship between the expression of Artemin protein and clinicopathologic features of gastric cancer was analyzed. Results：The positive rate of Artemin protein expression in gastric cancer tissue（ 77. 1%,94 /122） was higher than that in normal gastric mucosa（ 16. 3%,16/98; χ2= 80. 154,P 0. 001）. The positive rate of Artemin protein expression gradually increased with the deepened tumor invasion degree and increased TNM staging（ P 0. 05）; the expression of Artemin protein was relevant with lymph node metastasis（ χ2= 17. 835,P 0. 05） but not relevant with the degree of gastric cancer differentiation,gender or age of the patients（ P 0. 05）. Conclusion：Artemin may be involved in the occurrence and development of gastric cancer and is closely related with invasion and metastasis.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2013年第6期766-768,共3页
Journal of Zhengzhou University(Medical Sciences)
