摘要
目的 观察酸性成纤维细胞生长因子（aFGF）对创伤性脑水肿的作用。方法 大鼠脑损伤前应用aFGF持续脑室内注射12 h，观察脑含水量、病理组织学和超微结构改变。结果 脑水肿和神经细胞结构损伤明显减轻。结论 aFGF具有明显减轻脑水肿和神经细胞保护作用。
：Objective To observe the effect of acidic fibroblastic growth factor (aFGF) on traumatic brain edema. Methods Recombinant human aFGF (10(g/ml) was continuously injected into the intraventricle for 12 h before brain traumatic injury in rats, and the brain water content was determined and the histological and ultrastructural changes in the brain tissue observed. Results Brain edema and neuronal damage were reduced remarkably by the administration of aFGF. Conclusion aFGF can obviously alleviate brain edema and neuronal damage.
出处
《第一军医大学学报》
CSCD
2000年第6期491-492,F002,共3页
Journal of First Military Medical University
基金
广东省科技攻关项目基金(99M04606G)
