摘要
肝细胞生长因子(hepatocyte growth factor,HGF)/c-Met与人类许多恶性肿瘤的生长、侵袭及转移密切相关,乳腺癌、卵巢癌、子宫内膜癌、肺癌及消化系肿瘤中均可见HGF/c-Met的激活与过表达.在肿瘤的生长和转移过程中,c-Met担当了重要的角色,针对HGF/c-Met通路的抗肿瘤研究也成为当今研究的热点.c-Met在消化系肿瘤中的表达有较多的报道,本文将相关的最新研究做一系统的阐述,以使临床工作者对目前的研究现状有系统的了解.
There is a close relationship between HGF/c-Met and many human cancers. The activation and overexpression of HGF/c-Met can cause the growth, invasion and metastasis of breast cancer, ovarian cancer, endometrial cancer, lung cancer, and digestive system tumors. Since c-Met plays an important role in the growth and metastasis of tumors, targeting the HGF/c-Met pathway has become a hotspot for anti-cancer research. Currently, there have been many reports about c-Met expression in digestive tumors. In this paper we try to elaborate the latest progress in research related to c-Met expression in digestive tumors, with an aim to help clinicians gain a systematic understanding of this issue.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第30期3230-3235,共6页
World Chinese Journal of Digestology
关键词
胃癌食管癌
大肠癌
c—Met
过表达
Gastric cancer
Esophageal cancer
Colorectal cancer
c-Met
Overexpression
