摘要
目的:探讨趋化性细胞因子受体CXCR4在大肠癌中的表达及其与预后的关系.方法:收集67例大肠癌患者手术标本,采用免疫组织化学方法检测肿瘤组织中CXCR4蛋白的表达和微血管密度,分析CXCR4的表达水平与临床病理特征和生存的关系.结果:大肠癌组织中CXCR4蛋白表达阳性率为56.7%(38/67),与患者的性别、年龄、肿瘤部位、T分期和病理类型无相关性(P>0.05),与淋巴结转移、临床分期、微血管密及生存相关.N0,N1和N2期CXCR4的阳性率分别为40.6%,68.2%,76.9%(P<0.05);Ⅰ+Ⅱ期和Ⅲ期CXCR4的阳性率分别为39.4%,73.5%(P<0.05).低MVD组CXCR4的阳性率显著低于高MVD组(36.4%vs74.3%,P<0.01);CXCR4阳性组较CXCR4阴性组有较高的复发/转移率(47.4%vs24.1%,P<0.05)和较低的3a无病生存率(32.6%vs71.3%,P<0.05).结论:CXCR4可能促进大肠癌的侵袭和转移以及血管生成并影响其预后.
AIM： To investigate the expression of chemokine receptor CXCR4 in colorectal carcinoma and its correlation with the clinicopathologic characteristics and prognosis.
METHODS： Immunohistochemistry was used to detect the expression of CXCR4 and tumor microvessel density （MVD） in 67 tissue specimens of colorectal carcinoma, and the correlation between the CXCR4 expression and clinicopathologic factors was evaluated.
RESULTS： The positive rate of CXCR4 expression was 56.7% in colorectal carcinoma, which was correlated with lymph node metastasis, clinical staging and MVD as well as the survival of patients, but not with the sex and age of patients, tumor location, T staging, and pathological types. The expression of CXCR4 was 40.6%,68.2% and 76.9% in cases of N0, N1 and N2 stage, 39.4% and 73.5% in cases of Ⅰ ＋ Ⅱ and Ⅲ stage, respectively. The positive rate of CXCR4 expression was significantly lower in the case with low MVD than that with high MVD （36.4% vs 74.3%, P 〈 0.01）, and the CXCR4-positive case had a higher recurrent or metastatic rate （47.4% vs 24.1%, P 〈 0.05） and a lower 3-year survival rate （32.6% vs 71.3%, P 〈 0.05） than the CXCR4- negative one.
CONCLUSION： Positive CXCR4 expression and high tumor MVD are associated with the poor prognosis of patients, and they can be used as potential predictive factors for the recurrence or metastasis of colorectal cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第7期772-776,共5页
World Chinese Journal of Digestology
关键词
CXCR4蛋白
大肠癌
微血管密度
预后
Chemokine receptor CXCR4
Colorecta carcinoma
Microvessel density
Prognosis
