摘要
核转录因子-κB(nuclear factor-κB,NF-κB)是通过调节其靶基因的表达,在机体免疫应答、炎症与肿瘤的发生发展过程中发挥着重要功能,因此也被认为是调控免疫应答、预防和治疗肿瘤与炎症的理想靶点。生物活性肽具有许多的生理活性功能和独特的营养特性,可广泛地应用于保健食品和医药产品。本文首先概括NF-κB的组成、结构特点及其激活途径,从肽类调节NF-κB的机制出发,结合本实验室和国外学者最新的研究成果,对生物活性肽调节NF-κB相关研究进行系统的介绍,提出生物活性肽在一定程度上可以干预NF-κB信号通路,为生物活性肽作为相关疾病生物免疫治疗提供新的途径。
Nuclear factor- κB （NF-κB） has been reported to play an important role in immunity, inflammation and carcinogenesis by regulating the expression of its target genes. Thus, NF-κB was recognized as a promising target for the prevention and treatment of cancer and inflammation. Because bioactive peptides have many physiological functions and unique nutritional properties, it can be widely used in the fields of functional foods and medicinal products. In this paper, the compositions, structural characteristics and activation pathways of NF-κB are outlined. Recent research advances in the regulation and therapeutic effects of bioactive peptides on NF-κB pathways are reviewed. Moreover, the future development prospects of bioactive peptides are also proposed.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2013年第21期379-388,共10页
Food Science
基金
国家自然科学基金项目(31071522)
