摘要
基于头孢噻肟钠 (CTX)在 0 .10mol LNaOH溶液中水浴降解产物含有巯基 ( -SH) ,在pH 4 .5NaAc HAc介质中 ,于银微电极上产生一灵敏的吸附伏安还原峰 ,峰电位Ep =- 0 55V(vs.SCE)。示差脉冲溶出峰电流与CTX浓度在 1.0× 10 -7～ 1.0× 10 -5mol L范围内呈线性关系。方法可应用于模拟样品CTX的检测 ,令人满意。
A differential pulse cathodic stripping voltammetry (DPCSV) has been established for the determination of cefotaxime(CTX) on silver microdisk electrode. The degradation product of CTX was carried out in 0.1 mol/L NaOH at 100℃ for 20 min. The method is based on the electrochemical behavior of the degradation product of CTX containing thiohydroxy group(-SH), which can combine with Ag + to form an insoluble thiolate. In pH 4.5 NaAc HAc medium a sensitive reduction peak of the degradation product of CTX was obtained at silver microdisk electrode with cyclic voltammetry. The reduction peak currents are proportional to the concentration of CTX in the range of 1.0×10 -7 ～1.0×10 -5 mol/L by DPCSV. This method has been successfully applied to the determination of CTX in simulant sample.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2000年第11期1371-1374,共4页
Chinese Journal of Analytical Chemistry
基金
安徽省教委基金
关键词
头孢噻肟钠
降解产物
银微盘电极
伏安法
测定
Cefotaxime, degradation product, silver microdisk electrode, differential pulse cathodic stripping voltammetry
