摘要
目的 探讨 p15 ,Rb基因在肝细胞肝癌 (HCC)的表达情况、相互关系及其临床病理意义 .方法 用免疫组织化学方法 (SABC法 )检测 p15 ,Rb基因在 30例 HCC标本中的表达 .结果 p15基因阳性表达率为 6 3% ,Rb基因阳性表达率为 43% .p15 ,Rb基因阳性表达率在肿瘤分级间比较分别为 P<0 .0 5 ,P>0 .0 5 .p15 ,Rb基因在 HCC中阳性表达率无差异 (P>0 .0 5 ) .结论 p15 ,Rb基因在 HCC的发生、发展过程中起重要作用 ,HCC中 p15与 Rb基因的阳性表达不呈负相关 .
AIM To investigate p15 and Rb genes expression in hepatocellular carcinoma (HCC) and their clinico pathological significance. METHODS Immunohistochemical method (SABC) was used to detect the p15 and Rb gene expression in 30 cases of HCC. RESULTS Positive rates of p15, Rb gene are 63%, 43% respectively. The comparisons of positive rates of p15 and Rb gene expression between tumor grades were P <0.05, P >0.05 respectively. There were no differences between positive rates of p15 and Rb genes in HCC ( P >0.05). CONCLUSION p15 and Rb genes play an important role in the development of HCC. There were no negative relationships between positive expressions of p15 and Rb genes in HCC.
出处
《第四军医大学学报》
2000年第11期1333-1335,共3页
Journal of the Fourth Military Medical University
