摘要
目的探讨WWOX和STAT3在人肝细胞癌组织中的表达及其与临床病理参数的关系，并分析两者之间的相关性。方法应用免疫组织化学法检测60例肝细胞癌组织和癌旁组织中WWOX和STAT3的表达情况。结果WWOX在60例肝细胞癌中的阳性表达率为35．00％，显著低于癌旁组织中的表达（70，00％）（P〈0．05）。STAT3在肝细胞癌中的阳性表达率为71．67％，明显高于癌旁组织（36．67％）（P〈0．05）。WWOX蛋白表达与临床分期、肿瘤直径、肿瘤细胞分化密切相关（P〈0．05）；STAT3的表达与脉管癌栓、术后复发、肿瘤直径、肿瘤细胞分化密切相关（P〈0．05）。WWOX和STAT3蛋白的表达呈显著负相关（r=-0．392，P：0．002）。结论WWOX失活和STAT3高表达可能在肝细胞癌的发生及进展中有重要作用。
Objective To investigate the expression profiles and clinicopathologic parameters of WWOX and STAT3 in hepatocellular carcinoma（HCC） and to study their relationship. Methods 60 clinical HCC samples and paired adjacent normal tissues were assessed by immanohistochemisty staining method for WWOX and STAT3. Results The positive expression rate of WWOX in HCC was 35, 00% ,which was apparently lower than adjacent normal tissues （ 70.00% , P 〈 0.05 ）. The positive expression rate of STAT3 in HCC was 71.67% , which was obviously higher than adjacent normal tissues （36.67 % , P 〈 0.05 ）. The negative WWOX staining was significantly correlated with clinical stage, diameter of tumor and differentiation of tumor. The positive expression of STAT3 was significantly correlated with blood vessel thrombosis, recurrence of tumor, diameter of tumor and differentiation of tumor. There was a significantly negative relationship of WWOX with STAT3. Conclusion WWOX inactivation and STAT3 overexpression might be involved in carcinogenesis and progression of the HCC.
出处
《实用肿瘤学杂志》
CAS
2013年第1期21-25,共5页
Practical Oncology Journal
基金
广西自然科学基金项目（2012GXNSFAA053162）
