摘要
目的:观察清化益髓方防治化疗相关不良反应的临床疗效。方法:128例肿瘤科化疗患者随机分为治疗组65例和对照组63例,两组患者化疗前均常规给予5-羟色胺3(5-HT3)受体阻滞药止吐:托烷司琼5 mg,静脉推注,每天1次。治疗组患者在化疗当天加用自拟清化益髓方,水煎服,每日1剂。10 d为1个疗程。结果:治疗组在控制化疗引起的迟发性恶心呕吐、白细胞计数下降、化疗相关性便秘和改善Karnofsky评分方面均优于对照组,两组比较差异有统计学意义(P<0.05);在控制急性恶心呕吐的发生率方面,两组比较差异无统计学意义(P>0.05);治疗组在血红蛋白、血小板计数减少方面低于对照组,但差异无统计学意义(P>0.05)。结论:清化益髓方可有效降低化疗引起的迟发性恶心呕吐和白细胞下降的发生率,有效预防化疗相关性便秘的发生,改善肿瘤患者的体能状态。
OBJECTIVE：To observe clinical efficacy of Qinghua yisui fang for prevention and treatment of adverse drug reaction induced by chemotherapy.METHODS：128 patients underwent chemotherapy in oncology department were randomly divided into treatment group（65 cases）and control group（63 cases）.2 groups were given 5-HT3 receptor blocker,tropisetron 5 mg,intravenous push,once a day.Treatment group was given Qinghua yisui fang,decocted in water for oral dose,a dose a day.A treatment course lasted for 10 days.RESULTS：The improvement of tardive nausea and vomiting,the decrease of leucocyte count,chemotherapy-related constipation and Karnofsky score in treatment group were all better than in control group;there was statistical significance（P0.05）.The incidence of acute nausea and vomiting controlling had no statistical significance between 2 groups（P 0.05）.Hemoglobin and the decrease of blood platelet count in treatment group were lower than in control group,there was no statistical significance（P0.05）.CONCLUSIONS：Qinghua yisui fang can reduce the incidence of tardive nausea and vomiting and the decrease of leucocyte count,prevent chemotherapy related constipation effectively and improve physical state of tumor patients.
出处
《中国药房》
CAS
CSCD
2013年第35期3335-3337,共3页
China Pharmacy
关键词
清化益髓方
化疗
不良反应
Qinghua yisui fang
Chemotherapy
Adverse drug reaction
