摘要
目的 了解四氢巴马汀对哇巴因诱发家兔在体心脏延迟后除极和触发性室性心律失常的影响及作用机制。方法 家兔 14只 ,分为四氢巴马汀组和对照组 ,记录家兔右室单相动作电位和体表Ⅱ导联心电图 ,比较用哇巴因前后两组的单相动作电位和心电图变化。结果 两组的延迟后除极发生率和迟后除极配对间期差异无显著性 ,P >0 .0 5 ,但四氢巴马汀组的迟后除极振幅和触发性室性心律失常的发生率明显低于对照组 ,P <0 .0 5。结论 四氢巴马汀具有降低哇巴因诱发家兔在体心脏延迟后除极振幅的作用 ,从而减少由延迟后除极所引起的触发性室性心律失常的发生。
Objective To study the effect and mechanism of tetrahydropalmatine (THP) ouabain-induced on delayed after depolarization (DAD) and anti-triggered ventricular arrhythmia in in-vivo rabbit heart. Methods 14 rabbits were divided into two groups at random, control group and THP group. The monophasic action potential (MAP) of right ventricule and the surface lead Ⅱ electrocardiogram (ECG) were simultaneously recorded. The changes of MAP and ECG in the THP group were compared with those in the control group after administration of ouabain 150～170ug/kg and before using the drug. Results The incidence and couple interval of DAD in the two groups had no apparent difference (P>0.05) after administration of ouabain, but the amplitude of DAD and the incidence of triggered ventricular arrhythmia in the THP group were significantly lower than those in the control group (P<0.05). Conclusion THP had the effect of decreasing the amplitude of DAD of rabbit heart induced by ouabain thus reducing the chance of triggered ventricular arrhythmia induced by DAD.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2000年第10期667-669,共3页
Chinese Journal of Internal Medicine
