摘要
应用哇巴因或乌头碱静脉注射后迅速导致大鼠心律失常，然后分别给予降钙素基因相关肽（ＣＧＲＰ，实验组）或生理盐水（对照组）。结果哇巴因诱发心律失常的大鼠实验组（ｎ＝７）全部存活，而对照组（ｎ＝６）仅１只存活，死亡率８３％，两者之间具有显著性差异（Ｐ＜０．０５）．从心律失常评分来看，实验组与对照组亦有显著性差异（Ｐ＜０．０５）。乌头碱诱发的心律失常大鼠中，实验组（ｎ＝７）全部存活，其中５只出现稳定的窦性心律，平均持续时间为２０．９３±１３．２４ｍｉｎ，而对照组（ｎ＝６）４只存活，仅１只出现稳定的窦性心律，平均持续时间为２．１７±４．８４ｍｉｎ，两者之间具有显著性差异（Ｐ＜０．０５）；从心律失常评分来看，实验组在输入ＣＧＲＰ的４～８ｍｉｎ时即与对照组出现显著性差异（Ｐ＜０．０５）。以上结果说明ＣＧＲＰ对哇巴因和乌头碱导致的大鼠心率失常有明显治疗作用。
The purpose of the present study is to observe the therapeutic effects of calcitonin generelated peptide on arrhythmias caused by ouabain or aconitine in rats.3 minutes afterthe appearance of arrhythmia induced by ouabain (11 mg/ kg,iv)or aconitine(60 μg/kg, iv),the animals were divided into two groups at random which were infused with normalsaline(as control)or CGRP(40 μg/kg),respectively.In ouabain model,only one survived,while the other five(83%)died.In CGRP group,survival rate is 100% (7/7).In aconitine model,only four survived (4/6),one animal returned to stable sinus rhythm, with mean persistent time of 2.17 ± 4.84 min.In CGRP group,survival rate is 100 %(7/7),five returned to stable sinus rhythm with mean persistent time of 20.93±13.24 min ,compared with control group,P<0.05.The results show that,the therapeutic effects of CGRP on arrhythmias caused by ouabain or aconitine are obvious.
