摘要
目的 观察血液透析对慢性肾衰患者血浆内皮素 (ET)水平的影响以及ET水平与血压和超滤量之间的关系。方法 正常对照 2 0例、慢性肾功能衰竭维持性血透患者 30例 ,放射免疫法测定血浆ET ,同时检测血清Scr、BUN。结果 对照组血浆ET为 (5 2 .30± 7.2 6 )pg ml;患者组透析前后ET分别为(2 5 6 .0 6± 139.6 8)pg ml ,(2 2 5 .83± 10 7.5 2 )pg ml;慢性肾衰患者血透前后血浆ET水平浓度明显高于对照组(P <0 .0 1,P <0 .0 1) ;血透后ET水平较血透前降低 ,但无统计学意义 (P >0 .0 5 ) ,伴高血压的血透患者血浆ET水平明显高于血压正常者 ,超滤量 >2 .0kg者血ET水平较超滤量 <2 .0kg者显著增高 (P <0 .0 1)。结论 血浆ET水平增高与高血压互为促进因素 ,可形成恶性循环 ,加速肾功能损害 ;故应保持血透间期体重增加 <2 .0kg ,以降低ET增高幅度。
Objective To investigate plasma ET in patients with chronic renal failure and effects of hemodialysis on ET.To research the possible relationship between concentration of plasma ET and blood presure and quantity of ultrafitration liquid.Methods To set up the control group that has 20 case of healthy adults and 30 patients with chronic renal faiure.The levels of plasma ET were determined by radioimmuoassay.Results The results showed that the levels of ET were (52.30±7.26)pg/ml in the 20 cases of healthy adults;and (256.06±139.68)pg/ml and (225.83±107.52)pg/ml before and after hemodialysis in patients with chronic renal failure,both significantly higher than those in the control group (P<0.01,P<0.01).After hemodialysis the plasma ET was decreased but concentrition was changed insignificantly(P<0.05).Levels of plasma ET in the hemodialysis patients with hypertension were obviously different fron those with nomal bloodpresure.But levels of ET were higher in the patients with hypertension than those with normal bloodpresure.Plasma of ET was sinificantly higher in the hemodialysis patients of quantity of ultrafitration liquid>2.0 kg than quantity of liquid(P<0.01) Conclusion We can find the significant relationship between the levels of plasma ET and hypertension in the hemodialysispatients and both act mutually stimulatively.It may form a vicious circle and quicken up renal function injure.In order to reduce the extent that levels of ET increased,It ought to keep gaining weight<2.0 kg in the interphase of hemodialysis.
出处
《河北医药》
CAS
2000年第11期815-816,共2页
Hebei Medical Journal
