摘要
通过给小鼠静脉输注^(125)Ⅰ—内皮素,研究其在体内的分布及血液动力学情况。内皮素在血液中的分布相半衰期T_(1/2(1))5.56min,消除相半衰期T_(1/2(2))为3.5h。静脉给药后,肺、肾等组织有特异性分布。我们还通过分别给小鼠不同比活度的^(125)Ⅰ标记的内皮素iv,比较其组织分布和血液动力学情况。
Endothelin (ET) is a potent and long - acting vasoconstrictor peptide consisiting of 21 amino acids, and recently isolated from a medium of cultured porcine endothelial cells. To study its tracer kinetics property, we injected 125I -labelled ET into rat veins. The results are shown that the half time of the distribution phase and that of the elimina-
tion phase of 125I-ET in plasma are 5. 56 ±0. 04 min and 210. 13±38. 09 min, respectively. The125 - ET were widely distributed in various organs. The lung and kindney were the tissues with the highest grain density. Study of those in mouse blood and tissues showed similar results. KEY WORDS endothelin; tracer kinetics; dynamics; tissues; plasma
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第3期191-195,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题
