摘要
目的 为研究IL－10在肺癌免疫中的作用.方法 本研究采用酶联免疫吸附试验,对63例肺癌(鳞癌、腺癌)手术切除标本及离肺癌组织边缘5cm以上的肺组织的IL－10、IL－2、IFN－γ的含量进行了检测；结果 正常肺组织、肺癌组织所含IL－10、IL－2、IFN－γ不同,肺癌组织所含IL－10明显高于正常肺组织(P＜0．001),正常肺组织所含IL－2、IFN－γ较肺癌组织高(P＜0．05).结论 肺癌微环境中IL－10增加,IL－2、IFN－γ下降。
Objectives To explore the effect of IL－10 in lung cancer immunoregulatory． Methods Sixty－three cases＇ samples of Lung cancer tissue removed from operation and 31 cases＇ Lung tissue 5cm away from cancer were determined with enzyme－linked immunosorbent assay ELISA． The contents of IL－10IL－2IFN－γ in pulmonary cancer and normal tissue were comparatively analyzed． Results The contents of IL－10IL－2IFN－γ were different in normal pulmonary tissue from in and cancer tissue The level of IL－10 in cancer tissue was significantly higher than that in normal pulmonary tissue P＜0．01IL－2IFN－γ in normal pulmonary tissue were significantly higher than that in pulmonary cancer tissue P＜0．05． Conclusions The level of IL－10 in cancer tissue is significantly higher than that in normal lung tissue It may play an active immunoregulatory role in the lung cancer microenvironment．
出处
《江西医药》
CAS
2000年第5期259-260,共2页
Jiangxi Medical Journal
关键词
肺
肺肿瘤
免疫学
细胞因子
血液
ELISA
lung／immunology lung neoplasms／immunology cytokine／blood ELISA
