摘要
目的:探讨p16和PCNA表达在卵巢癌发病中的作用。方法:应用SABC免疫组化技术,检测40例卵巢上皮性癌、12例良性卵巢肿瘤和10例正常卵巢中p16和PCNA的表达,并对二者表达在卵巢上皮性癌临床分期、组织学分级、组织学类型和生存时间之关系进行探讨。结果:①p16阳性表达多见于临床期别早、高分化和生存期长的病例组,阴性多见于临床期别晚、低分化和生存期短的病例组(P<0.05)。②PCNA指数在临床期别晚、低分化和生存期短的病例组明显高于临床期别早、高分化和生存期长的病例组(分别均为P<0.01)。③p16表达与PCNA指数呈反向相关性。结论:p16和PCNA表达与卵巢上皮性癌的临床病理指标有关,在其发病中有重要作用。
Objective:To explore the role of p16 and PCNA expression in the progression of ovarian cancer. Methods: Using immunohistochemical staining technique, the expression of pl6、PCNA were examined in 40 cases of ovarian epithelial cancers, 12 cases of benign ovarian tumors and 10 cases of normal ovaries.The relationship between the expression of p16、PCNA and the clinical stage, differentiated grade, histological type and survival time were analyzed. Results: (1) The majority of well clinical stage, high differentiated grade and long survival time were positive for p16 which was negative in most of the poorly clinical stage, low differentiated grade and short survival time(P<0.05) . (2) The PCNA expression correlated with the clinical stage, differentiated grade and survival time. The PCNA index in the poorly clinical stage, low differentiated grade and short survival time were higher than those in the well clinical stage, high differentiated grade and long survival time(P< 0.01 respectively) . (3) There was negative correlation between the expression of p16 and PCNA index.Conclusion: The expression of p16、PCNA closely correlate the clinicopathological parameters of ovarian cancer and play some important value in progression of ovarian epithelial cancer.
出处
《临床肿瘤学杂志》
CAS
2000年第3期167-169,共3页
Chinese Clinical Oncology
