摘要
目的探讨头孢哌酮/舒巴坦联合米诺环素在治疗鲍氏不动杆菌感染的临床疗效,指导临床合理用药。方法回顾性分析医院2010年10月-2012年10月使用头孢哌酮/舒巴坦联合米诺环素治疗的124例鲍氏不动杆菌感染患者的临床资料,总结其药敏试验、临床疗效和不良反应。结果鲍氏不动杆菌对头孢哌酮/舒巴坦和米诺环素有高度敏感性,分别为76.6%和100.0%,对氨苄西林、氨曲南、呋喃妥因、头孢唑林的耐药性最强,均为100.0%;采用头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染患者的总有效率为72.6%,细菌清除率35.5%,患者中14例出现轻微的恶心、腹胀等,加用药物治疗后缓解。结论根据鲍氏不动杆菌的药敏试验,采用头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染患者有良好的效果、不良反应少、安全性高。
OBJECTIVE To discuss the effect of cefoperazone/sulbactam combined with minocyline on treatment of Acinetobacter baumannii infections so as to guide the reasonable clinical use of antibiotics.METHODS The clinical data of 124cases of Acinetobacter baumannii infections treated by cefoperazone/sulbactam joint with minocyline were retrospective analyzed,and the conditions of drug sensitive test,clinical curative effect and minocyline adverse reaction.RESULTS The sensitivities of A.baumannii against cefoperazone/sulbactam high were notable higher than the other antimicrobial agents.The resistance of A.baumannii was high to ampicillin,ammonia QuNa,nitrofurantoin,cefazolin,and the drug resistance rates were 100%.The total effective rate was 72.6%,and the bacteria clearance rate was 35.5%.There were 14cases of patients with such adverse reactions as mild nausea and abdominal distension,which were relieved after drug treatment.CONCLUSIONAccording to the drug susceptibility testing,the cefoperazone/sulbactam combined with minocyline can achieve good effect on the treatment of the patients with A.baumannii infections,with the adverse reactions less,and safety high.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第16期4042-4043,4046,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
多耐药性
米诺环素
头孢哌酮
舒巴坦
Acinetobacter baumannii
Multidrug-resistance
Minocyline
Cefoperazone/sulbactam
