摘要
目的了解鲍曼不动杆菌的临床分布特征、对常用抗菌药物的耐药特点,指导临床合理使用抗菌药物。方法收集了148株临床分离的鲍曼不动杆菌,对其标本来源、科室分布进行分析。采用Vitek 2细菌鉴定及药敏分析仪作鉴定及药敏试验,并同时补充米诺环素及头孢哌酮/舒巴坦的纸片扩散法药敏试验,统计分析其对米诺环素等14种抗菌药物的药敏结果。结果鲍曼不动杆菌主要分布于重症监护病房(ICU)及神经外科,痰液为主要标本来源。该菌对米诺环素、头孢哌酮/舒巴坦、阿米卡星、氨苄西林/舒巴坦、亚胺培南、复方新诺明、左氧氟沙星、妥布霉素、哌拉西林/他唑巴坦、庆大霉素、环丙沙星、头孢吡肟、头孢他啶及头孢曲松的耐药率分别为0.7%、0.7%、13.5%、46.6%、64.2%、71.6%、75.7%、70.3%、52.0%、79.1%、79.1%、78.4%、81.8%、87.8%。结论鲍曼不动杆菌多重耐药现象严重,可使用米诺环素、头孢哌酮/舒巴坦、阿米卡星等药物来治疗。医院应重视对鲍曼不动杆菌的耐药性监测,同时还需加强对ICU、神经外科病房及呼吸内科病房的管理。
Objective To investigate the distribution and resistance characteristic of clinical Acinetobacter baumannii isolates and to guide the empiric therapy for clinicians.Methods One hundred and fourty-eight clinical isolates of Acinetobacter baumannii were collected.Isolate identification and antimicrobial susceptibility testing were carried out by Vitek 2 bacterial identification and susceptibility analyzers.The susceptibilities to Minocycline and cefoperazone / sulbactam were carried out by disk diffusion method.Antimicrobial susceptibility datum were analyzed by statistical method.Results Acinetobacter baumannii was mainly distributed in the ICU（intensive care unit）and neurosurgery wards and sputum was the main source of specimen.The resistance rates to minocycline,cefoperazone / sulbactam,amikacin,ampicillin / sulbactam,imipenem,cotrimoxazole,levofloxacin,tobramycin,piperacillin / he tazobactam,gentamicin,ciprofloxacin,cefepime,ceftazidime and ceftriaxone were 0.7%,0.7%,13.5%,46.6%,64.2%,71.6%,75.7%,70.3% 52.0%,79.1%,79.1%,78.4%,81.8%,87.8%,separately.Conclusion The resistance situation against Acinetobacter baumannii was serious,while minocycline,cefoperazone / sulbactam,amikacin were the optional drugs.The hospital should pay attention to drug-resistant Acinetobacter baumannii,and strengthen the infection control of ICU,neurosurgery and respiratory medical ward.
出处
《检验医学与临床》
CAS
2013年第2期155-156,共2页
Laboratory Medicine and Clinic
关键词
鲍曼不动杆菌
临床分布
耐药性
Acinetobacter baumannii
clinical distribution
resistance
