摘要
目的分析医院鲍氏不动杆菌感染的现状,为合理、快速、有效地治疗鲍氏不动杆菌感染提供依据。方法对2009年1月-2010年2月112例鲍氏不动杆菌感染患者临床资料进行评价分析。结果鲍氏不动杆菌对氨苄西林、头孢呋辛敏感率较低,分别为10.71%、11.90%,对其他几种常用抗菌药物敏感率均>50.00%,其中,敏感率最高的是美罗培南,为91.76%;使用最多的抗菌药物是β-内酰胺酶抑制剂复合制剂为24.85%、头孢菌素类为24.54%、青霉素类为14.42%、头霉素类为8.28%和氟喹诺酮类为7.06%;抗菌药物使用存在不合理的现象,其中用法用量不当、联用不当、换药过于频繁、预防用药疗程偏长、选药不当分别占41.98%、33.33%、11.11%、7.41%。结论用药过程中,医师应严格根据药敏试验结果选药;联合用药应有明确的指证;按说明书和药物特性使用抗菌药物,避免不合理用药。
OBJECTIVE To analyze the current situation of Acinetobacter baumannii infections so as to provide evidence for reasonable, rapid, effective treatment of A. baumannli infections. METHODS A total of 112 cases of patients with A. baumannii infections which were selected from Jan 2009 to Feb 2010 were analyzed and evaluated. RESULTS The drug susceptibility testing showed that the drug susceptibility rates of the A. baumannii strains to ampicillin and cefuroxime were 10.71 % and 11.90%, respectively, the drug susceptibility rate to other commonly used antibiotics was more than 50.00%, and the drug susceptibility rate to meropenem was the highest （91.76%）. The most frequently used drugs were the β-lactamase inhibitor complex（24. 85%）, cephalosporins （24.54%）, penicillins（14.42%）, cephalomycins（8.28%）and fluoroquinolones（7.06%）. There were unreasonable phenomena in the use of antibiotics, including dosage and usage error （41.98 %）, improper combined medication （33. 33%）, frequent drug repIacement（11. 11%）, prolonged course of preventive treatment（7. 41%）, and improper selection of drugs（6.17%）. CONCLUSION In the process of medication, the doctors should select ap- propriate drugs by referring to the drug susceptibility testing. Combined medication must have definite indications. To avoid the irrational drug use, the usage of medicine must be in line with the instructions and the characteristics of antibacterial drugs.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第12期2988-2990,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
药物敏感性试验
抗菌药物
不合理用药
Acinetobacter baumanii
Drug susceptibility testing
Antibiotics
Irrational medication
