摘要
目的 探讨临床烧伤创面愈合过程中成纤维细胞生长因子 (FGF)的变化及其作用。方法 采用免疫组织化学方法 ,对烧伤创面肉芽中心部、肉芽与愈合皮肤的交界部、愈合皮肤部和自身正常皮肤 ,以及 度烧伤创面不同部位和 度烧伤创面愈合过程中 FGF表达变化进行了观察。结果 度烧伤创面不同部位 FGF表达强度不同 ,以创面的肉芽中心部 FGF含量最多 ,肉芽与愈合皮肤的交界部 FGF含量次之 ,愈合皮肤 FGF含量较少 ;每个创面 FGF以中层含量较多 ,正常皮肤 FGF无明显表达。 度烧伤创面伤后 14天时 FGF含量最多。结论烧伤创面愈合过程中内源性 FGF变化与创面愈合密切相关 ,临床合理应用 FGF有助于创面愈合。
Objective\ To investigate the changes of fibroblast growth factor(FGF) in burn wounds.Methods\ The FGF expression in the center of wound granulation, the edge of wound, the healed part of wound, the normal skin of patients, and the heal course of second degree burn wounds were detected by immunohistochemical methods.Results\ The expression intensity of FGF was different in the different sites of third degree burn wounds. The highest contents of FGF was in the center granulation of burn wounds, the less was in the borderline of wound and healed skin, and the least was in the healed skin. FGF expression mainly concentrated in the middle layer of wound, and almost no FGF expression in normal skin. The most FGF expression was occured at 14 days after injury in second degree of burn wound. Conclusion The changes of FGF in wounds are closely related to the wound healing, and rational use of FGF can promote wound healing.
出处
《中国修复重建外科杂志》
CAS
CSCD
2000年第5期261-263,共3页
Chinese Journal of Reparative and Reconstructive Surgery
