摘要
目的探讨颈部风寒湿刺激对机体颈椎间盘组织中白介索－１β（ＩＬ－１β）ｍＲＮＡ的影响。方法３０只新西兰白兔，随机分为正常对照组、风寒湿组、低头位组、复合模型组和中药治疗组等５组，每组６只，观察颈椎间盘组织中ＩＬ－１β的变化。结果风寒湿与低头位等颈椎病常见的致病因素可使颈椎间盘组织ＩＬ－１β ｍＲＮＡ表达出现异常，芪麝颈康方对此有一定作用。结论ＩＬ－１β的异常表达可能是风寒湿致颈椎病的重要机理之一。
Objective To probe into the change of IL - 1β mRNA in cervical disks due to the influence of wind cold dampness in experimental rabbits. Methods Thirty New Zealand rabbits were randomly separated into five groups(six group). RT - PCR was employed to observe the expression of interleudin - 1β mRNA in tissure from the cervical intervertebra discs beween the groups. Results Unusual up-expression of IL - 1β mRNA in the discs of experimental animals could be picked out in the experimental groups. Conclusion The results showed that il - 1β appeared to be the coupling factor/between the exopathic factors and the degradation of cervical intervertebral discs, which may show some insight on the mechanism of wind cold dampness action on cervical spondylosis.
出处
《现代康复》
CAS
CSCD
2000年第8期1190-1191,共2页
Modern Rehabilitation
