期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

B型脑钠肽和D-二聚体在冠心病合并糖尿病中的表达及其临床意义 被引量：4

暂未订购
导出
摘要 目的探讨B型脑钠肽(BNP)和D-二聚体(DD)在冠心病(CHD)合并糖尿病(DM)中的表达及其临床意义。方法收集冠心病(CHD)患者355例,根据病情分为急性冠脉综合征(ACS)组152例,稳定型心绞痛(SA)组203例;收集无CHD病史的健康体检者192例作为对照组;再根据DM的诊断标准将各组研究对象分为合并DM及非合并DM组。并同时测定所有研究对象的血浆BNP及DD水平。结果 ACS组DM患病率为49.3%(75/152),SA组为23.2%(47/203),对照组为9.3%(18/192),CHD患者DM患病率明显高于对照组,ACS组DM患病率明显高于SA组,差异有统计学意义(P<0.05)。CHD患者血浆BNP和DD水平均明显高于对照组,差异有统计学意义(P<0.05);ACS组DD及BNP的表达均高于SA组,差异有统计学意义(P<0.05)。CHD合并DM患者BNP和DD的表达均明显高于非合并DM患者(P<0.05)。CHD合并DM患者血浆BNP和DD水平呈正相关(r=0.729,P<0.05)。结论 CHD与DM互为危险因素,BNP与DD在对患者预后的危险分层方面,是互补的独立预测因素。
作者 林养 吴春芳 黄诗韵 黄梓就
机构地区 湛江市第四人民医院检验科
出处 《国际检验医学杂志》 CAS 2013年第12期1612-1613,共2页 International Journal of Laboratory Medicine
关键词 冠心病 糖尿病 B型钠尿肽 D-二聚体
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

  • 1King H, Aubert RE, Herman WH. Global burden of diabetes,1995-2025 : prevalence, numerical estimates, and projections [J],Diabetes Care, 1998,21 .9) : 1414-1431.
  • 2Bartnik M,Malmberg K.Hamsten A,et al. Abnormal glucose tol-erance-a common risk factor in patients with acute myocardial in-farction in comparison with population-based controls[J]. J InternMed,2004,256(4) :288-297.
  • 3中国心脏调查组,胡大一,潘长玉.中国住院冠心病患者糖代谢异常研究——中国心脏调查[J].中华内分泌代谢杂志,2006,22(1):7-10. 被引量：476
  • 4Tycinska AM,Sobkowicz B,Mroczko B,et al. the value of apelin-36and brain natriuretic peptide measurements in patients withfirst ST-elevation myocardial infarction[J], Clin Chim Acta,2010,411C23/24):2014-2018.
  • 5Yamashita T,Seino Y,Ogawa A,et al. N-terminal pro-BNP isanovel biomarker for integrated cardio-renal burden and enrly riskstratification in patients admitted for cardiac emergency[J]. J Car-diol,2010,55(3) :377-383.
  • 6Gosselin RC, Owings JT, Kehoe J, et al. Comparison of six D-di-mer methods in patients suspected of deep vein thrombosis[J].Blood Coagul Fibrinolysis,2003 ,14(6) :545-550,.
  • 7Righini M,Perrier A, De Moerloose P, et al, D-Dimer for venousthromboembolism diagnosis; 20 years later[J]. J Thromb Haem-ost, 2008 ,6(7) : 1059-1071.
  • 8Hargett CW, Tapson VF. Clinical probability and D-dimer tes-ting: how should we use them in clinical practice. [J]. Semin Re-spir Crit Care Med,2008,29( 1) : 15-24.

二级参考文献13

  • 1李素青,田玉华,朱敏,杨超元.中老年糖尿病流行病学调查方法探讨[J].实用老年医学,1996,10(4):175-176. 被引量：13
  • 2King H,Aubert RE,Herman WH.Global burden of diabetes 1995-2025.Prevalence,numerical estimates and projections.Diabetes Care,1998,21:1414-1431.
  • 3Bartnik M,Malmberg K,Hamsten A,et al.Abnormal glucose tolerance-a common risk factor in patients with acute myocardial infarction in comparison with population-based controls.J Int Med,2004,256:288-297.
  • 4Coutinho M,Gerstein HC,Wang Y,et al.The relationship between glucose and incident cardiovascular events:a metaregression analysis of published data from 20 studies of 95 783 individuals followed for 12.4years.Diabetes Care,1999,22:233-240.
  • 5The DECODE study group on behalf of the European Diabetes Epidemiology Group.Glucose tolerance and cardiovascular mortality.Arch Int Med,2001,161:397-404.
  • 6Bartnik M,Malmberg K,Norhammar A,et al.Newly detected abnormal glucose tolerance:an important predictor of long-term outcome after myocardial infarction.Eur Heart J,2004,25:1990-1997.
  • 7Norhammar A,Tenerz A,Nilsson G,et al.Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus:a prospective study.Lancet,2002,359:2140-2144.
  • 8Bartnik M,Ryden L,Ferrari R,et al.The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe:the Euro Heart Survey on diabetes and the heart.Eur Heart J,2004,25:1880-1890.
  • 9Hashimoto K,Ikewaki K,Yagi H,et al.Glucose intolerance is common in Japanese patients with acute coronary syndrome who were not previously diagnosed with diabetes.Diabetes Care,2005,28:1182-1186.
  • 10Choi KM,Lee KW,Kim SG,et al.Inflammation,insulin resistance,and glucose intolerance in acute myocardial infarction patients without a previous diagnosis of diabetes mellitus.J Clin Endocrinol Metab,2005,90:175 -180.

共引文献475

同被引文献18

引证文献4

二级引证文献10

国际检验医学杂志
2013年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部