摘要
目的探讨B型脑钠肽(BNP)在老年肺部感染患者血浆中的变化规律,为老年肺部感染患者的诊治及预后的评估提供依据。方法用电化学发光法测定老年肺部感染患者血浆BNP水平及治疗后的变化。结果对照组BNP水平为(113.2±85.7)pg/ml,BNP异常率为4.4%,肺部感染组BNP水平为(4874.2±3070.5)pg/ml,BNP异常率为91.3%,心功能不全组BNP水平为(7925.2±6618.6)pg/ml,BNP异常率为100.0%,均较对照组明显升高(P<0.05);经系统治疗有效患者BNP水平可降至(597.6±312.6)pg/ml,较感染组明显降低,差异有统计学意义(P<0.05);按照患者预后分组,存活组BNP水平为(4213.4±3692.4)pg/ml,而死亡组BNP水平为(13 492.0±10 414.4)pg/ml,明显高于存活组,差异有统计学意义(P<0.05)。结论肺部感染可导致老年患者BNP升高,且对其预后有一定的预测价值。
OBJECTIVE To study the potential role and prognostic value of change of B-type brain natriuretic peptide（BNP） in plasma of the senile patients with pulmonary infections so as to provide basis for the clinical diagnosis and treatment of pulmonary infections as well as the evaluation of the prognosis. METHODS The levels of plasma BNP in the senile patients with pulmonary infections were measured by chemiluminescence immumoassay method, and the change of BNP after the treatment was also observed. RESULTS The level of BNP in the control group was （113.2± 85. 7）pg/ml with the abnormal rate of 4. 4%, while the level of BNP in the pulmonary infection group was （4874.2±3070.5） pg/ml with the abnormal rate of 91.3%, and the level of BNP in the heart failure group was （7925.2±6618.6） pg/ml with the abnormal rate of 100.0%, significantly higher than that of the control group the difference was statisticauy significant （P〈0.05）. After the systematic treatment, the level of plasma BNP of the senile patients with pulmonary infections was （597. 6±312. 6） pg/ml, significantly decreased as compared with the infection group （P〈0.05）. The patients were divided according to the prognosis, the level of BNP of the senile patients was （4213.4±3692.4） pg/ml in the survival group, （13 492±10 414.4） pg/ml in the death group, the level of plasma BNP in the death group was significantly higher than that in the survival group the difference was statisticauy significant （P〈0.05）. CONCLUSION The pulmonary infections can lead to the elevated level of plasma BNP, which may has certain value in predicting the prognosis of the senile patients with pulmonary infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第2期251-253,共3页
Chinese Journal of Nosocomiology
关键词
老年
肺部感染
B型脑钠肽
水平
预后
Senile
Pulmonary infection
Brain natriuretic peptide
Level
Prognosis
