摘要
目的:探讨高敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与冠心病(coronary heart disease,CHD)严重程度的相关性,为CHD临床诊治及预后评估提供依据。方法:将本院收治的81例CHD患者按冠状动脉造影结果分为单支狭窄组(SN组)21例、双支狭窄组(DN组)33例及多支狭窄组(MN组)27例,选取同期入院体检的健康志愿者33例为对照组;比较各组患者血清hs-CRP水平及冠脉造影积分(Gensini评分),并分析hs-CRP与Gensini评分的相关性。以hs-CRP水平中位数为标准将所有CHD患者分为低CRP组44例和高CRP组37例,分别完成6个月随访,比较随访期两组患者预后不良心血管事件发生率。结果:对照组、SN组、DN组及MN组患者血清hs-CRP水平与Gensini评分均依次上升,各组之间相比有显著性差异(P<0.05);经直线相关分析,血清hs-CRP水平与Gensini评分呈直线正相关(P<0.05)。所有患者均成功完成随访,高CRP组随访期心血管事件发生率显著高于低CRP组(P<0.05)。结论:血清hs-CRP水平与CHD的严重程度有显著相关性,可用于CHD诊治及预后评估。
objective： To high sensitivity C - reactive protein, the hs CRP） level and coronary heart disease （ coronary heart diseases, CHD） correlation between the severity of, provide the basis for CHD clinical diagnosis and treatment and prognosis assess- ment. Methods： Will of 81 CHD patients admitted in our hospital according to coronary angiography results are divided into single ste- nosis group （SN） 21 cases, the double branch stenosis group （DN group） and 33 cases more than a narrow group of 27 cases （MN） , selected at the same time hospital check - up of 33 healthy volunteers as control group patients ; Compared between groups patients ser- um hs - integral level of CRP and coronary angiography （ Gensini score）, and analyze the hs - the correlation between CRP and Gensini score. Hs - median CRP level standards will be all divided into low CRP group of 44 patients with CHD and high CRP group of 37 cases, completed 6 months of follow - up, respectively, comparing the prognosis of patients with follow - up of two groups the in- cidence of adverse cardiovascular events. Results： Control group, SN group, the patients with DN and MN group serum hs CRP levels and Gensini scores are rising in turn, compared between each group with significant difference （ P 〈 0. 05 ） ; By linear correlation analy- sis, the hs - CRP serum levels and the Gensini score was linear positive correlation （ P 〈 0. 05 ）. all patients were successfully com- pleted follow - up follow - up high CRP group had a significantly higher incidence of cardiovascular events low CRP group （ P 〈 0.05 ）. Conclusion ： Hs - serum CRP level and CHD were significantly correlated with the severity of, can be used in the diagnosis and treat- ment of CHD and prognosis evaluation.
出处
《中国民族民间医药》
2013年第9期34-35,共2页
Chinese Journal of Ethnomedicine and Ethnopharmacy
