摘要
目的探讨中老年人群胰岛β细胞功能对糖代谢状态的影响。方法研究对象为2005年5月-2007年5月在我院行糖尿病筛查的中老年人群,所有受检者行75g口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)以评估糖代谢状态;根据OGTT结果分为糖耐量正常(nomal glucose tolerance,NGT)组、糖调节受损(impaired glucose tolerance,IGR)组及新诊断糖尿病(diabetes mellitus,DM)组,以校正胰岛素抵抗后的胰岛β细胞功能(HBCI/IR)评估β细胞功能,以胰岛素抵抗指数(HOMA-IR)作为胰岛素抵抗评估指标。结果共纳入756例受检者。糖代谢状态从NGT→IGR→DM,校正胰岛素抵抗后的胰岛β细胞功能(HBCI/IR)逐渐下降(P<0.001),而胰岛素抵抗指数(HOMA-IR)逐渐增加(P<0.001)。单因素直线回归分析显示HBCI/IR与糖代谢状态(β=-10.0;95%CI:-12.6,-7.3;P<0.001)显著相关。多因素直线回归分析显示,在调整性别、年龄、体重指数(BMI)、收缩压(SBP)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和胰岛素抵抗指数(HOMA-IR)后,胰岛β细胞功能(HBCI/IR)是中老年人群糖代谢状态的重要影响因素(β=-0.003;95%CI:-0.006,0.000;P<0.05)。结论胰岛β细胞功能是中老年人群糖代谢状态的重要影响因素。
Objective To study the effect of pancreaticβ-cell function on glucose metabolism in middle-aged and elderly subjects. Methods Middle-aged and elderly subjects for diabetes mellitus (DM) screening in our hospital from May 2005 to May 2007 were included in this study. Their glucose metabolism was tested by OGTT at the dose of 75g. The subjects were divided into normal glucose tolerance (NGT) group, impaired glucose tolerance (IGR) group and newly diagnosed DM group according to their OGTT. Their pancreatic β-cell function and insulin resistance were assessed, respectively, according to the HBCI/IR and HOMA-IR. Results A total of 756 subjects were included in this study. HBCI/IR showed that the glucose metabolism decreased gradually from NGT to IGR and from IGR to DM and the insulin resistance increased gradually (P<0.001). Univariate linear regression analysis revealed that the HBCI/IR was closely related with glucose metabolism (β=-10.0, 95%CI:-12.6 and-7.3, P < 0.001). Multivariate linear regression analysis displayed that the pancreaticβ-cell function was an important factor for glucose metabolism in middle-aged and elderly subjects after adjustment for sex, age, BMI, SBP, TG, HDL-C and HOMA-IR (β=-0.003, 95%CI:-0.006 and 0.000;P<0.05). Conclusion Pancreaticβ-cell function is an important factor for glucose metabolism in middle-aged and elderly subjects.
出处
《解放军医学院学报》
CAS
2013年第6期604-606,共3页
Academic Journal of Chinese PLA Medical School
关键词
中老年
糖代谢状态
胰岛Β细胞功能
middle and old age
glucose metabolism status
islet β cell function
