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胃癌基因改变的研究进展 被引量：1

Research progress of gene changes in gastric cancer
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摘要 癌基因激活和抑癌基因失活参与胃癌的发生发展.基因单碱基突变、基因小片段插入与缺失、微卫星不稳定性、杂合性缺失、启动子甲基化等遗传学与表观遗传学改变影响基因的表达,参与细胞的癌变过程和肿瘤的生长转移等.文章对胃癌常见的基因改变及其临床意义进行综述. Gastric cancer is one of the leading causes of cancer mortality in the world.The development and progression of gastric cancer is attributed to a number of genetic and epigenetic alterations of oncogene and tumor suppress gene.
作者 蒲汪旸(综述) 李凯 邢春根(审校)
机构地区 苏州大学附属第二医院肿瘤内科 苏州大学附属第二医院普外科 苏州大学药学院分子诊断与生物制药实验室
出处 《肿瘤研究与临床》 CAS 2013年第5期355-358,共4页 Cancer Research and Clinic
关键词 胃肿瘤 基因突变 微卫星不稳定性 杂合性缺失 启动子甲基化 Gastric neoplasms Gene mutation Microsatellite instability Loss of heterozygosity Promoter hypermethylation
分类号 R135.1 [医药卫生—劳动卫生]
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参考文献36

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二级参考文献22

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肿瘤研究与临床
2013年 第5期

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