摘要
目的探讨尿酸(uric acid,UA)在Ⅱ型糖尿病(type 2diabetes mellitus,T2DM)并发冠心病(coronaryheart disease,CHD)发生发展过程中的作用及其相关性因素。方法入选正常对照组(A组)40例,T2DM组(B组)80例,T2DM合并CHD组(C组)82例,收集一般临床资料,用全自动生化分析仪测定空腹血UA水平。应用SPSS13.0软件进行统计分析。结果血UA水平在C组较A组及B组均显著升高(P<0.05),但在A组和B组之间无显著性差异(P>0.05)。各组进行pearson相关分析显示,UA在A组与脂蛋白(a)[lipoprotein(a),LP(a)]呈正相关,与高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDLC)呈负相关,相关系数r分别为0.442(P=0.004)、-0.366(P=0.020),UA在B组与腰臀比(waist to hip ratio,WHR)、超敏C反应蛋白(high-sensitivity C-reactive protein,HsCRP)呈正相关,相关系数r分别为0.227(P=0.043)、0.301(P=0.007),在C组与年龄、HsCRP呈正相关,相关系数r分别为0.279(P=0.011)、0.292(P=0.008)。Logistic逐步回归分析显示,年龄、WHR、LP(a)、UA是T2DM并发CHD的独立危险因素。而HDLC是T2DM并发CHD的保护因素。结论 T2DM并发CHD患者UA显著升高,它是T2DM并发CHD的独立危险因素。
Objective To investigate the effect of uric acid（UA） on the occurrence and development of coronary heart disease （CHD） and their correlations in patients with type 2 diabetes mellitus （T3DM）. Methods 40 controls （group A）, 80 T2DM （group B） and 82 T2DM with CHD （group C） were recruited. The clinical data were collected for analysis. Fasting serum UA was detected by automatic biochemistry analyzer. Results Fasting serum UA in group C were significantly higher than that of the other two groups （P〈0. 05）, but no significant difference was found between group A and group B （P〉0.05）. All parameters were evaluated with the pearson correlation coefficient analysis in each group, UA was positively correlated with lipoprotein （a）[LP（a）] and negatively correlated with high density lipoprotein cholesterol（HDLC） in group A, with the correlation coefficients of 0. 442（P=0. 004）and 0. 366（P=0. 020）, respectively, and positively correlated with waist to hip ratio（WHR）, high-sensitivity C-reactive protein （HsCRP） in group B, with the correlation coefficients of 0. 227 （P = 0. 043） and 0. 301 （P= 0. 007）, respectively , and positively correlated with age, HsCRP in group C, with the correlation coefficients of 0. 279（P=0. 011） and 0. 292（P=0. 008）, respectively. Logistic regression analysis revealed that age, WHR, LP（a）, UA were the independent risk factors of T2DM with CHD, while HDLC exerted a protective function. Conclusion UA increases significanty in patients with both T2DM and CHD, and it is an independent risk factor of T2DM patients with CHD.
出处
《西部医学》
2012年第11期2089-2091,共3页
Medical Journal of West China
关键词
冠心病
糖尿病
尿酸
危险因素
Coronary heart disease
Diabetes
Uric aeid
Risk factors
