摘要
为研究复合食用真菌多糖对荷瘤和环磷酰胺抑制小鼠T细胞亚群的影响 ,采用猴头菇、香菇、茯苓 3种食用真菌的多糖等比混合作为总多糖 ,再按一定比例配以葡萄籽多酚和甘草酸 ,制成复合食用真菌多糖 ,观察其对荷瘤和环磷酰胺免疫抑制小鼠T细胞亚群的影响。结果显示 ,荷瘤鼠L3T4 、Lyt- 2细胞百分率以及L3T4 /Lyt - 2比值均明显下降 ,给予复合多糖和香菇多糖有明显的改善作用 ,其中复合多糖组恢复到正常小鼠水平。CP能明显降低正常小鼠的L3T4 细胞百分率以及L3T4 /Lyt- 2比值 ,对Lyt- 2作用不明显 ,但对荷瘤鼠来说 ,CP的治疗作用优于对免疫功能的抑制作用。复合多糖和香菇多糖能明显改善CP的毒副作用 ,并有一定的协同作用 。
The effects of compounds of edible fugus polysccharides(CEFP) i.e. hericium erinaceus, lentinus edodes and poria cocos with equal ratio, with procyanidins oligomers and glycyrrhetinicacid with certain ratio on mice T cell supressed by tumour and CP was observed. The results showed that the percentage of L 3T 4, lyt-2 and L 3T 4/lyt-2 in S-180 group dropped signficently, which were improved by CEFP and sacchardes lentinus edodes and the CEFP group recovered to normal control. It also showed that CP decreased the ratio of L 3T 4/lyt-2 and the L 3T 4 level, but had no effects on lyt-2. It was found that therapy effects of CP on tumor mice was effective except for its immunity inhibition. CEFP and sacchardes lentinus edodes could resist the negative effects of CP significantly and had concord effects. CEFP effects were better than that of sacchardes lentinus edodes only, which showed the importance of the compounds of antitumor effective substance. Author's address Liu Changxi, Institute of Food Safety Control and Inspection, Ministry of Health, Beijing 100021 PRC.
出处
《中国食品卫生杂志》
2000年第5期3-6,共4页
Chinese Journal of Food Hygiene
基金
国家自然科学基金!(No39840016)资助课题的部分内容
