摘要
１９９１年～１９９３年对１７１例恶性肿瘤患者的Ｔ细胞亚群、淋巴细胞转化率及巨噬细胞吞噬率进行了观察。并对其中６０例患者采用了枸杞多糖（ＬｙｃｉｕｍＢａｒｂａｒｕｍＰｏｌｙｓａｃｃｈａｒｉｄｅＬＢＰ）加放疗和单纯放疗随机分组研究。结果显示，恶性肿瘤患者淋巴细胞Ｔ３、Ｔ４细胞比例、Ｔ４／Ｔ８比值、淋巴细胞转化率及巨噬细胞吞噬率明显低于正常人，Ｔ８细胞比例上升。单纯放疗组放疗后Ｔ３、Ｔ４细胞比例、Ｔ４／Ｔ８比值、淋巴细胞转化率及巨噬细胞吞噬率均较放疗前明显下降，外周血白细胞数及淋巴细胞绝对值也明显降低。ＬＢＰ＋放疗组除外周血白细胞数及淋巴细胞绝对值维持原水平外，以上参数均较放疗前明显增加。提示枸杞多糖可以提高放疗患者的免疫功能，对治疗肿瘤有较好的辅助作用。
Tlymphocyte blastogenetic rate and phagocytosis rate of macrophages were studied on 171 patients with malignant tumors during the perlod 1991-1993. Sixty of 171 cases were divided randomly into two groups; the patients of the first group were treated with radiotherapy and lycium barbarum polysaccharide, while the second group with radiotherapy alone. Compared with the normal controls ,T3, T4,T4/T8 raito, lympocyte blastogenesis rate and phagocytosis rate of macrophages in the patients decreased markedly, while T8 increased relatively. The results showed that in the second group, T3, T4, T4/T8 ratio, lyrnphocyte blastogenesis rate , macrohpage phagocytosis rate, leucocyte and lymphocyte counts of peripheral blood declined. notably after radiotherapy.In the first group,however, the above parameters increased significantly, except that leucocyte and lymphocyte counts of peripheral blood maintained unchanged. It is suggested that lycium barbarum polysaccharide can raise the immune responses of the cancer patients during radiotherapy and therefore can be of potential benefit to cancer therapy.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
1996年第1期18-20,共3页
Chinese Journal of Radiological Medicine and Protection
关键词
肿瘤
淋巴细胞
巨噬细胞
枸杞多糖
放射疗法
Turnor, immunity, lymphocyte, macrophages, lycium barbarum polysaccharide, radiotherapy
